kurskvestЧеловек и его здоровьеHumans and their health1998-57461998-5754Kursk State Medical University10.21626/vestnik/2020-2/07kurskvest-830Research ArticleМЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИMEDICOBIOLOGICAL SCIENCESОценка эффективности фармакологической коррекции экспериментального остеопороза глюкозамина сульфатом, стронция хлоридом и их комбинациейEvaluation of the effectiveness of pharmacological correction of experimental osteoporosis by glucosamine sulfate, strontium chloride, and their combinationhttps://orcid.org/0000-0001-5862-6143АникановАлександр ВасильевичAnikanovAleksandr V.

аспирант кафедры травматологии и ортопедии

Full-Time Postgraduate of Traumatology and Orthopedics Department

anikanov015@gmail.comhttps://orcid.org/0000-0003-3777-6622АртюшковаЕлена БорисовнаArtyushkovaElena B.

д-р биол. наук, профессор, профессор кафедры фармакологии, директор НИИ экспериментальной медицины

DBSc, Professor, Professor of Pharmacology Department, Director of Research Institute of Experimental Medicine

eartyushkova@mail.ruhttps://orcid.org/0000-0003-3759-6373ФайтельсонАлександр ВладимировичFaitelsonAleksandr V.

д-р мед. наук, профессор, профессор кафедры травматологии и ортопедии

DM, Professor, Professor of Traumatology and Orthopedics Department

fajtelsonav@kursksmu.nethttps://orcid.org/0000-0003-2868-0776РаджкумарДенсинг Самуэл РаджRajkumarDensingh Samuel Raj

канд. мед. наук, доцент, доцент кафедры травматологии и ортопедииканд. мед. наук, доцент, доцент кафедры травматологии и ортопедии

PhD in Medicine, Associate Professor, Associate Professor of Traumatology and Orthopedics Department

densingh7@gmail.comКурский государственный медицинский университетРоссияKursk State Medical UniversityRussian Federation202025062020025056Copyright © Аниканов А.В., Артюшкова Е.Б., Файтельсон А.В., Раджкумар Д.С., 20202020Аниканов А.В., Артюшкова Е.Б., Файтельсон А.В., Раджкумар Д.С.Anikanov A.V., Artyushkova E.B., Faitelson A.V., Rajkumar D.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.kursk-vestnik.ru/jour/article/view/830Цель

Цель: исследовать остеопротективную активность глюкозамина сульфата, стронция хлорида и их комбинации на модели экспериментального остеопороза у лабораторных животных (OVX-модель) в сравнении с препаратом Строметта и контролем (OVX без коррекции).

Материалы и методы

Материалы и методы. Материалом для исследования служили самки белых крыс линии Wistar массой 250±30 г. Для моделирования остеопороза выполнялась билатеральная овариэктомия. Оценка микроциркуляции производилась методом допплеровской флоуметрии. Применялась цифровая рентгеновская денситометрия для определения костной плотности. С помощью гистологической морфометрии исследован поперечный размер трабекул спонгиозной костной ткани.

Результаты

Результаты. По таким параметрам, как костная плотность, микроциркуляция и средняя ширина костных трабекул, установлены достоверные различия по сравнению с контролем (OVX без коррекции) для групп с коррекцией глюкозамина сульфатом, стронция хлоридом и их комбинацией, и таким образом был подтвержден их остеопротективный эффект.

Заключение

Заключение. Глюкозамина сульфат, стронция хлорид и их комбинация в перспективе могут быть применены для медикаментозной профилактики остеопороза в период постменопаузы. Однако для введения в клиническую практику стронция хлорида и его комбинации с глюкозамина сульфатом необходимо провести полные доклинические и клинические испытания.

Objective

Objective. To study the osteoprotective activity of glucosamine sulfate, strontium chloride, and their combinations on a model of experimental osteoporosis in laboratory animals (OVX model) in comparison with the Strometta preparation and control (OVX without correction).

Materials and methods

Materials and methods. The material for the study was female Wistar rats weighing 250 ± 30 g. To simulate osteoporosis, bilateral ovariectomy was performed. Microcirculation was evaluated by Doppler flowmetry. Digital X-ray densitometry was used to determine bone density. Using histological morphometry, the transverse size of the trabeculae of the spongy bone tissue was studied.

Results

Results. In such parameters as bone density, microcirculation, and the average width of bone trabeculae, significant differences were established compared with the control (OVX without correction) for groups with correction of glucosamine sulfate, strontium chloride, and their combination, and thus their osteoprotective effect was confirmed.

Conclusion

Conclusion. In the future, glucosamine sulfate, strontium chloride, and their combination can be used for drug prevention of osteoporosis in the postmenopausal period. However, for the introduction of strontium chloride and its combination with glucosamine sulfate into clinical practice, it is necessary to conduct complete preclinical and clinical trials.

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The authors declare that there are no conflicts of interest present.