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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">kurskvest</journal-id><journal-title-group><journal-title xml:lang="ru">Человек и его здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Humans and their health</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-5746</issn><issn pub-type="epub">1998-5754</issn><publisher><publisher-name>Kursk State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21626/vestnik/2020-2/03</article-id><article-id custom-type="elpub" pub-id-type="custom">kurskvest-826</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Некоторые аспекты коморбидности у госпитализированных больных терапевтического стационара</article-title><trans-title-group xml:lang="en"><trans-title>Some aspects of comorbidity in hospitalized patients of a therapeutic hospital</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4387-7737</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пырикова</surname><given-names>Наталья Викторовна</given-names></name><name name-style="western" xml:lang="en"><surname>Pyrikova</surname><given-names>Natalia V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, доцент, профессор кафедры факультетской терапии и профессиональных болезней</p></bio><bio xml:lang="en"><p>DM, Associate Professor, Professor of Faculty Therapy and Occupational Diseases Department</p></bio><email xlink:type="simple">allinatali@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6233-7202</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антропова</surname><given-names>Оксана Николаевна</given-names></name><name name-style="western" xml:lang="en"><surname>Antropova</surname><given-names>Oksana N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, профессор кафедры факультетской терапии и профессиональных болезней</p></bio><bio xml:lang="en"><p>DM, Professor, Professor of Faculty Therapy and Occupational Diseases Department</p></bio><email xlink:type="simple">antropovaon@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6845-6173</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осипова</surname><given-names>Ирина Владимировна</given-names></name><name name-style="western" xml:lang="en"><surname>Osipova</surname><given-names>Irina V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, зав. кафедры факультетской терапии и профессиональных болезней</p></bio><bio xml:lang="en"><p>DM, Professor, Head of Faculty Therapy and Occupational Diseases Department</p></bio><email xlink:type="simple">i.v.osipova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1651-8755</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фролова</surname><given-names>Ирина Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Frolova</surname><given-names>Irina A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студентка</p></bio><bio xml:lang="en"><p>Student</p></bio><email xlink:type="simple">irinafrolova536@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Алтайский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Altai State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>25</day><month>06</month><year>2020</year></pub-date><volume>0</volume><issue>2</issue><fpage>16</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пырикова Н.В., Антропова О.Н., Осипова И.В., Фролова И.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Пырикова Н.В., Антропова О.Н., Осипова И.В., Фролова И.А.</copyright-holder><copyright-holder xml:lang="en">Pyrikova N.V., Antropova O.N., Osipova I.V., Frolova I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.kursk-vestnik.ru/jour/article/view/826">https://www.kursk-vestnik.ru/jour/article/view/826</self-uri><abstract><p>Цель исследования - провести анализ факторов риска (ФР) неинфекционных заболеваний в зависимости от индекса коморбидности (ИК) у госпитализированных больных.</p><sec><title>Материалы и методы</title><p>Материалы и методы. Одномоментное поперечное сравнительное исследование выполнено в Краевом государственном бюджетном учреждении здравоохранения «Алтайский краевой госпиталь для ветеранов войн». Принять участие в исследовании предложено 128 поступившим в течение месяца в терапевтическое отделение, согласились 100 человек (отклик 78,1%). Средний возраст - 77,9±8,3 года, 48% женщин, 52% - мужчин. Проведено общеклиническое обследование, анализ ФР неинфекционных заболеваний, психосоциальных факторов, монреальская шкала оценки когнитивных функций (MoCA-тест), осмотр невролога для выявления энцефалопатии. На основании данных ИК Чарльсона (Charlson) больные были разделены на три группы: 1 группа - ИК 1-2 балла - 46%, 2 группа - ИК 3-4 балла - 38%, 3 группа - ИК 5 и более баллов - 16%.</p></sec><sec><title>Результаты</title><p>Результаты. Независимо от пола ИК 5 и более встречался чаще, чем ИК 1-2 на 16,8%, а среди мужчин ИК 5 и более имел место чаще, чем ИК 3-4 на 17,8%; лица среднего возраста были только в группе с ИК 1-2. У пациентов с ИК 5 и более, по сравнению с пациентами с ИК 1-2, была выше частота таких ФР, как ожирение (на 29,9%, абдоминальное ожирение имели все лица с ИК 5 и более), социальная изоляция (на 29,7%), тип личности D (на 36,5%), а также когнитивных нарушений (на 28,5%) и энцефалопатии (на 32,9%). Депрессия установлена на 26,1% чаще у пациентов с ИК 3-4, чем у больных с ИК 1-2.</p></sec><sec><title>Заключение</title><p>Заключение. Коморбидность - не обязательное состояние, характерное для стареющего населения, это прежде всего результат поведения индивидуума. Поэтому выявление и коррекция ФР неинфекционных заболеваний, особенно в условиях коморбидности, представляется актуальной задачей, обусловливающей успех лечения данной категории пациентов.</p></sec></abstract><trans-abstract xml:lang="en"><p>Objective - to analyze the risk factors (RF) of noncommunicable diseases depending on the comorbidity index (CI) in hospitalized patients.</p><sec><title>Materials and methods</title><p>Materials and methods. A cross-sectional study was performed at the Altai Regional Hospital for War Veterans. 128 people were invited to take part in the study during the month in the therapeutic department, 100 people agreed (78.1% response). The average age is 77.9±8.3 years, 48% of women, 52% of men. A general clinical examination, RF analysis of noncommunicable diseases, psychosocial factors, Montreal Cognitive Function Scale (MoCA test), and an examination by a neurologist to detect encephalopathy were performed. Based on the Charlson CI data, patients were divided into 3 groups: group 1 - CI 1-2 points - 46%, group 2 - CI 3-4 points - 38%, group 3 - CI 5 and more points - 16%.</p></sec><sec><title>Results</title><p>Results. Regardless of gender, CI 5 or more was more common than CI 1-2 by 16.8%; among men, CI 5 and more occurred more often than CI 3-4 by 17.8%; middle-aged persons were only in the group with CI 1-2. In patients with CI 5 or more, compared with patients with CI 1-2, there was a higher frequency of such RFs as obesity (by 29.9%, all persons with CI 5 or more had abdominal obesity), social isolation (by 29.7%), type D personality (by 36.5%), as well as cognitive impairment (by 28.5%) and encephalopathy (by 32.9%). Depression was found 26.1% more often in patients with CI 3-4 than in patients with CI 1-2.</p></sec><sec><title>Conclusion</title><p>Conclusion. Comorbidity is not a mandatory condition characteristic of an aging population, it is primarily the result of individual behavior. Therefore, the identification and correction of RF of noncommunicable diseases, especially in conditions of comorbidity, seems to be an urgent task, which determines the success of treatment in this category of patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>коморбидность</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>факторы риска</kwd><kwd>психосоциальные факторы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>comorbidity</kwd><kwd>cardiovascular disease</kwd><kwd>risk factors</kwd><kwd>psychosocial factors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Belyalov F.I. Treatment of diseases in conditions of comorbidity. Moscow: GEOTAR-Media, 2016. 544 p. (in Russ.). DOI: 10.18087/cardio.n431</mixed-citation><mixed-citation xml:lang="en">Belyalov F.I. Treatment of diseases in conditions of comorbidity. Moscow: GEOTAR-Media, 2016. 544 p. (in Russ.). DOI: 10.18087/cardio.n431</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Boytsov S.A., Luk’yanov M.M., Yakushin C.S., Martsevich S.Yu., Vorob’yev A.N., Zagrebel’nyy A.V., Pereverzeva K.G., Pravkina E.A., et al. The outpatient based registry RECVASA: prospective follow-up data, risk evaluation and outcomes in cardiovascular patients. Cardiovascular therapy and prevention. 2015;14(1):53-62 (in Russ.). DOI: 10.15829/1728-8800-2015-1-53-62</mixed-citation><mixed-citation xml:lang="en">Boytsov S.A., Luk’yanov M.M., Yakushin C.S., Martsevich S.Yu., Vorob’yev A.N., Zagrebel’nyy A.V., Pereverzeva K.G., Pravkina E.A., et al. The outpatient based registry RECVASA: prospective follow-up data, risk evaluation and outcomes in cardiovascular patients. Cardiovascular therapy and prevention. 2015;14(1):53-62 (in Russ.). DOI: 10.15829/1728-8800-2015-1-53-62</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Boytsov S.A., Pogosova N.V., Bubnova M.G., Drapkina O.M., Gavrilova N.E., Eganyan R.A., Kalinina A.M., Karamnova N.S., et al. Cardiovascular prophylaxis 2017. Russian national recommendations. Russian journal of cardiology. 2018;23(6):7-122 (in Russ.). DOI: 10.15829/1560-4071-2018-6-7-122</mixed-citation><mixed-citation xml:lang="en">Boytsov S.A., Pogosova N.V., Bubnova M.G., Drapkina O.M., Gavrilova N.E., Eganyan R.A., Kalinina A.M., Karamnova N.S., et al. Cardiovascular prophylaxis 2017. Russian national recommendations. Russian journal of cardiology. 2018;23(6):7-122 (in Russ.). DOI: 10.15829/1560-4071-2018-6-7-122</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Efremova E.V., Shutov A.M., Borodulina E.O. Problem of comorbidity in chronic heart failure. Ulyanovsky medico-biological journal. 2015;4:46-52 (in Russ.).</mixed-citation><mixed-citation xml:lang="en">Efremova E.V., Shutov A.M., Borodulina E.O. Problem of comorbidity in chronic heart failure. Ulyanovsky medico-biological journal. 2015;4:46-52 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Larina V.N., Bart B.Ya., Karpenko D.G., Starostin I.V., Larin V.G., Kulbachinskaya O.M. Polymorbidity and its association with the unfavorable course of chronic heart failure in outpatients aged 60 years and older. Kardiologiia. 2019;59(12S):25-36 (in Russ.). DOI: 10.18087/cardio.n431</mixed-citation><mixed-citation xml:lang="en">Larina V.N., Bart B.Ya., Karpenko D.G., Starostin I.V., Larin V.G., Kulbachinskaya O.M. Polymorbidity and its association with the unfavorable course of chronic heart failure in outpatients aged 60 years and older. Kardiologiia. 2019;59(12S):25-36 (in Russ.). DOI: 10.18087/cardio.n431</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mad’yanova V.V, Kakorina E.P., Klokova T.A. The characteristics of morbidity of population older than able-bodied age in the Russian federation in 2012-2018. Problems of social hygiene, public health and history of medicine, Russian journal. 2020;28(2):207-215 (in Russ.).</mixed-citation><mixed-citation xml:lang="en">Mad’yanova V.V, Kakorina E.P., Klokova T.A. The characteristics of morbidity of population older than able-bodied age in the Russian federation in 2012-2018. Problems of social hygiene, public health and history of medicine, Russian journal. 2020;28(2):207-215 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mal’chikova S.V., Maksimchuk-Kolobova N.S., Kazakovtseva M.V. Comorbidity in elderly patients with atrial fibrillation affects the "cost of illness". Farmakoekonomika. Modern pharmacoeconomic and pharmacoepidemiology. 2019;12(3):191-199 (in Russ.). DOI: 10.17749/2070-4909.2019.12.3.191-199</mixed-citation><mixed-citation xml:lang="en">Mal’chikova S.V., Maksimchuk-Kolobova N.S., Kazakovtseva M.V. Comorbidity in elderly patients with atrial fibrillation affects the "cost of illness". Farmakoekonomika. Modern pharmacoeconomic and pharmacoepidemiology. 2019;12(3):191-199 (in Russ.). DOI: 10.17749/2070-4909.2019.12.3.191-199</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mamedov M.N., Zvolinskaya E.Yu., Akhmedova E.B., SHepel’ R.N. The basic principles of lifestyle changes in patients with comorbidity CNID. Oganov R.G., Drapkina O.M., editors. Moscow, 2018. 126 р. (in Russ.). DOI: 10.17116/profmed2018rekcomorbidity</mixed-citation><mixed-citation xml:lang="en">Mamedov M.N., Zvolinskaya E.Yu., Akhmedova E.B., SHepel’ R.N. The basic principles of lifestyle changes in patients with comorbidity CNID. Oganov R.G., Drapkina O.M., editors. Moscow, 2018. 126 р. (in Russ.). DOI: 10.17116/profmed2018rekcomorbidity</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Nizov A.A., Suchkova E.I., Dashkevich O.V., Trunina T.P. Cardiovascular comorbidity in the actual clinical practice of an outpatient physician. Comparative register study in the Ryazan Region. Cardiovascular therapy and prevention. 2019;18(2):70-75 (in Russ.). DOI: 10.15829/1728-8800-2019-2-70-75</mixed-citation><mixed-citation xml:lang="en">Nizov A.A., Suchkova E.I., Dashkevich O.V., Trunina T.P. Cardiovascular comorbidity in the actual clinical practice of an outpatient physician. Comparative register study in the Ryazan Region. Cardiovascular therapy and prevention. 2019;18(2):70-75 (in Russ.). DOI: 10.15829/1728-8800-2019-2-70-75</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Oganov R.G., Simanenkov V.I., Bakulin I.G., Bakulina N.V., Barbarash O.L., Boytsov S.A., Boldueva S.A., Garganeeva N.P., et al. Comorbid pathology in clinical practice. Diagnostic and treatment algorithms. Cardiovascular therapy and prevention. 2019;18(1): 5-66 (in Russ.). DOI: 10.15829/1728-8800-2019-1-5-66</mixed-citation><mixed-citation xml:lang="en">Oganov R.G., Simanenkov V.I., Bakulin I.G., Bakulina N.V., Barbarash O.L., Boytsov S.A., Boldueva S.A., Garganeeva N.P., et al. Comorbid pathology in clinical practice. Diagnostic and treatment algorithms. Cardiovascular therapy and prevention. 2019;18(1): 5-66 (in Russ.). DOI: 10.15829/1728-8800-2019-1-5-66</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Orlova Ya.A., Tkacheva O.N., Arutyunov G.P., Kotovskaya Yu.V., Lopatin Yu.M., Mareyev V.Yu., Mareyev Yu.V., Runikhina N.K., et al. Features of diagnostics and treatment of chronic heart failure in elderly and senile patients. Expert opinion of the Society of Experts in Heart Failure, Russian Association of Gerontologists, and Euroasian Association of Therapists. Kardiologiia. 2018;58(12S):42-72 (in Russ.). DOI: 10.18087/cardio.2560</mixed-citation><mixed-citation xml:lang="en">Orlova Ya.A., Tkacheva O.N., Arutyunov G.P., Kotovskaya Yu.V., Lopatin Yu.M., Mareyev V.Yu., Mareyev Yu.V., Runikhina N.K., et al. Features of diagnostics and treatment of chronic heart failure in elderly and senile patients. Expert opinion of the Society of Experts in Heart Failure, Russian Association of Gerontologists, and Euroasian Association of Therapists. Kardiologiia. 2018;58(12S):42-72 (in Russ.). DOI: 10.18087/cardio.2560</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Sarsenbayeva G.I., Tursynbekova A.E. Modern approaches to the assessment of comorbidity in patients. CardioSomatics. 2019;10(1):19-23 (in Russ.). DOI: 10.26442/22217185.2018.4.180073</mixed-citation><mixed-citation xml:lang="en">Sarsenbayeva G.I., Tursynbekova A.E. Modern approaches to the assessment of comorbidity in patients. CardioSomatics. 2019;10(1):19-23 (in Russ.). DOI: 10.26442/22217185.2018.4.180073</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Starodubova A.V., Varayeva Yu.R., Egorova V.V., Brumberg A.A. The principles of nutrition for the elderly. Moskovskaya meditsina. 2019;2(30):36-41 (in Russ.).</mixed-citation><mixed-citation xml:lang="en">Starodubova A.V., Varayeva Yu.R., Egorova V.V., Brumberg A.A. The principles of nutrition for the elderly. Moskovskaya meditsina. 2019;2(30):36-41 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tkacheva O.N., Runikhina N.K., Kotovskaya Yu.V., Sharashkina N.V., Ostapenko V.S. Arterial hypertension management in patients aged older than 80 years and patients with the senile asthenia. Cardiovascular therapy and prevention. 2017;16(1):8-21 (in Russ.). DOI: 10.15829/1728-8800-2017-1-8-21</mixed-citation><mixed-citation xml:lang="en">Tkacheva O.N., Runikhina N.K., Kotovskaya Yu.V., Sharashkina N.V., Ostapenko V.S. Arterial hypertension management in patients aged older than 80 years and patients with the senile asthenia. Cardiovascular therapy and prevention. 2017;16(1):8-21 (in Russ.). DOI: 10.15829/1728-8800-2017-1-8-21</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Tkacheva O.N., Runikhina N.K., Ostapenko V.S., Sharashkina N.V., Mkhitaryan E.A., Onuchina Yu.S., Lysenkov S.N. Validation of the questionnaire for screening frailty. Advances in gerontology. 2017;30(2):236-242.</mixed-citation><mixed-citation xml:lang="en">Tkacheva O.N., Runikhina N.K., Ostapenko V.S., Sharashkina N.V., Mkhitaryan E.A., Onuchina Yu.S., Lysenkov S.N. Validation of the questionnaire for screening frailty. Advances in gerontology. 2017;30(2):236-242.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Frolova E.V. The clinical features of heart failure in elderly and old age. Kardiologiia. 2018;58(S8):4-11 (in Russ.). DOI: 10.18087/cardio.2487</mixed-citation><mixed-citation xml:lang="en">Frolova E.V. The clinical features of heart failure in elderly and old age. Kardiologiia. 2018;58(S8):4-11 (in Russ.). DOI: 10.18087/cardio.2487</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Buta B.J., Walston J.D., Godino J.G., Park M., Kalyani R.R., Xue Q-L., Bandeen-Roche K., Varadhan R. Frailty assessment instruments: systematic characterization of the uses and contexts of highly - cited instruments. Ageing Res Rev. 2016;26:53-61. DOI: 10.1016/j.arr.2015.12.003</mixed-citation><mixed-citation xml:lang="en">Buta B.J., Walston J.D., Godino J.G., Park M., Kalyani R.R., Xue Q-L., Bandeen-Roche K., Varadhan R. Frailty assessment instruments: systematic characterization of the uses and contexts of highly - cited instruments. Ageing Res Rev. 2016;26:53-61. DOI: 10.1016/j.arr.2015.12.003</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Charlson M.E., Pompei P., Ales K.L., MacKenzie C.R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373-383. DOI: 10.1016/0021-9681(87)90171-8</mixed-citation><mixed-citation xml:lang="en">Charlson M.E., Pompei P., Ales K.L., MacKenzie C.R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373-383. DOI: 10.1016/0021-9681(87)90171-8</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">DuGoff E.H., Canudas-Romo V., Buttorff C., Leff В., Anderson G.F. Multiple chronic conditions and life expectancy: a life table analysis. Med Care. 2014;52(8):688-694. DOI: 10.1097/MLR.0000000000000166</mixed-citation><mixed-citation xml:lang="en">DuGoff E.H., Canudas-Romo V., Buttorff C., Leff В., Anderson G.F. Multiple chronic conditions and life expectancy: a life table analysis. Med Care. 2014;52(8):688-694. DOI: 10.1097/MLR.0000000000000166</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Forman D.E., Arena R., Boxer R., Dolansky M.A., Eng J.J., Fleg J.L., Haykowsky M., Jahangir A., et al. Prioritizing functional capacity as a principal end point for therapies oriented to older adults with cardiovascular disease: a scientific statement for healthcare professionals from the American Heart Association. Circulation. 2017;135(16):e894-918. DOI: 10.1161/CIR.0000000000000483</mixed-citation><mixed-citation xml:lang="en">Forman D.E., Arena R., Boxer R., Dolansky M.A., Eng J.J., Fleg J.L., Haykowsky M., Jahangir A., et al. Prioritizing functional capacity as a principal end point for therapies oriented to older adults with cardiovascular disease: a scientific statement for healthcare professionals from the American Heart Association. Circulation. 2017;135(16):e894-918. DOI: 10.1161/CIR.0000000000000483</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Nasreddine Z.S., Phillips N.A., Bederian V., Charbonneau S., Whitehead V., Collin I., Cummings J.L., Chertkow H. The Montreal cognitive assessment (MoCA): a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695-699. DOI: 10.1111/j.1532-5415.2005.53221.x</mixed-citation><mixed-citation xml:lang="en">Nasreddine Z.S., Phillips N.A., Bederian V., Charbonneau S., Whitehead V., Collin I., Cummings J.L., Chertkow H. The Montreal cognitive assessment (MoCA): a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695-699. DOI: 10.1111/j.1532-5415.2005.53221.x</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Piepoli M.F., Hoes A.W., Agewall S., Albus C., Brotons C., Catapano F.L., Cooney M-T., Corra U., et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention &amp; Rehabilitation (EACPR). Eur Heart J. 2016;37(29):2315-2381. DOI:10.1093/eurheartj/ehw106</mixed-citation><mixed-citation xml:lang="en">Piepoli M.F., Hoes A.W., Agewall S., Albus C., Brotons C., Catapano F.L., Cooney M-T., Corra U., et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention &amp; Rehabilitation (EACPR). Eur Heart J. 2016;37(29):2315-2381. DOI:10.1093/eurheartj/ehw106</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Vasan R.S., Xanthakis V., Lyass A., Andersson C., Tsao C., Cheng S., Aragam J., Benjamin E.J., Larson M.J. Epidemiology of Left Ventricular Systolic Dysfunction and Heart Failure in the Framingham Study. JACC: Cardiovascular Imaging. 2018;11(1): 1-11. DOI: 10.1016/j.jcmg.2017.08.007</mixed-citation><mixed-citation xml:lang="en">Vasan R.S., Xanthakis V., Lyass A., Andersson C., Tsao C., Cheng S., Aragam J., Benjamin E.J., Larson M.J. Epidemiology of Left Ventricular Systolic Dysfunction and Heart Failure in the Framingham Study. JACC: Cardiovascular Imaging. 2018;11(1): 1-11. DOI: 10.1016/j.jcmg.2017.08.007</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Vermeiren S., Vella-Azzopardi R., Beckwée D., Habbig A-K., Scafoglieri A., Jansen B., Bautmans I. Frailty and the Prediction of Negative Health Outcomes: A Meta-Analysis. J Am Med Dir Assoc. 2016;17(12):1163.e1-1163.el7. DOI: 10.1016/j.jamda.2016.09.010</mixed-citation><mixed-citation xml:lang="en">Vermeiren S., Vella-Azzopardi R., Beckwée D., Habbig A-K., Scafoglieri A., Jansen B., Bautmans I. Frailty and the Prediction of Negative Health Outcomes: A Meta-Analysis. J Am Med Dir Assoc. 2016;17(12):1163.e1-1163.el7. DOI: 10.1016/j.jamda.2016.09.010</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
