Objective: to analyze the influence of Indolicidin analogues N7 and N8 on the prooxidant-antioxidant balance in animals with acute periodontitis. Materials and methods. Acute periodontitis was simulated according to the method supposed by Volozhin A.I. and Vinogradova S.I. (1990). Indolicidins N 7 and N 8 were injected intraperitoneally at the dose 500 mcg/kg daily for 7 days after periodontitis modeling had been over. The animals were withdrawn from the experiment on the 7th, 14th and 21st days after periodontitis modeling. The concentration of malonic aldehyde and acylhydroperoxides, as well as the catalase and superoxide dismutase activity in plasma were determined by traditional methods. Results. The modeling of acute periodontitis to Wistar rats is accompanied with the activation of lipid peroxidation, which manifests itself by the accumulation of malonic dialdehyde and acylhydroperoxides. The decrease in the activity of antioxidant enzymes - superoxide dismutase and catalase - was shown in the blood of experimental animals throughout the whole experiment. The administration of Indolicidin analogues stimulated the lipid peroxidation only in the beginning (7 days) of periodontitis. Indolicidins N 7 and N8 activated the action of superoxide dismutase and catalase. Conclusion. The stimulatory influence of investigated Indolicidins on the antioxidant enzyme activity in plasma was established in rats with periodontitis. No significant differences of the activity of the investigated Indolicidin analogues on the prooxidant-antioxidant balance in acute parodontitis were established compared to Indolicidin N 7 and Indolicidin N 8 effects.