References

kurskvest

Человек и его здоровье

Humans and their health

1998-57461998-5754

Kursk State Medical University

10.21626/vestnik/2018-3/09

kurskvest-393

Research Article

МЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИ

MEDICOBIOLOGICAL SCIENCES

Коррекция стресс-индуцированных нейроиммуноэндокринных нарушений у самцов крыс с низкой устойчивостью к стрессу применением транскраниальной электростимуляции

Correction of stress-induced neuromimuneendocrine disturbances in male rats with low stress sustainability by transcranial direct current stimulation

Липатова

А. С.

Lipatova

A. S.

noemail@neicon.ru

Каде

А. Х.

Kade

A. Kh.

noemail@neicon.ru

Трофименко

А. И.

Trofimenko

A. I.

noemail@neicon.ru

Поляков

П. П.

Polyakov

P. P.

noemail@neicon.ru

Кубанский государственный медицинский университетРоссияKuban State Medical UniversityRussian Federation

2018

07112018

035868

2018

Липатова А.С., Каде А.Х., Трофименко А.И., Поляков П.П.

Lipatova A.S., Kade A.K., Trofimenko A.I., Polyakov P.P.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.kursk-vestnik.ru/jour/article/view/393

Цель работы - изучение эффективности транскраниальной электростимуляции (ТЭС-терапии) для коррекции стресс-индуцированных нарушений гормонального и цитокинового статуса у крыс с низкой стрессоустойчивостью. В исследовании задействовано 3 группы крыс: группа № 1 - интактные, группа № 2 (без ТЭС-терапии) и № 3 (с ТЭС-терапией) - с низкой стрессоустойчивостью. Проведено два теста принудительного плавания на 1 и 7 сутки, на 8 сутки - ортостатический стресс с последующим забором крови. Ортостатический стресс в группе № 2 сопровождался ростом: адреналина на 88,9%, АКТГ в 10,5 раз, кортикостерона на 70,1%, ИЛ-1β на 178,2%, ИЛ-6 в 6,7 раза, ИЛ-10 на 37,1%, в сравнении с контролем. В группе № 3 продолжительность плавания крыс выросла на 47,7%. После ортостатического стресса выявлено снижение содержания: адреналина в 1,4 раза, АКТГ в 8,2 раза, кортикостерона в 1,4 раза, ИЛ-1β в 1,5 раза, ИЛ-6 в 2,2 раза, ИЛ-10 в 1,2 раза по отношению к группе № 2.

The goal of the research is to study the effectiveness of transcranial direct current stimulation (tDCS) for correcting stress-induced hormonal and cytokine disturbances in rats with low stress sustainability. There were 3 groups of rats: group 1 - intact, group 2 (without tDCS) and group 3 (with tDCS) - with low stress sustainability. Two forced swimming tests were carried out on days 1 and 7, on the 8th day - orthostatic stress with subsequent collection of blood. Orthostatic stress in group 2 was accompanied by growth: adrenaline by 88.9%, ACTH 10.5 times, corticosterone by 70.1%, IL-1β by 178.2%, IL-6 by 6.7 times, IL- 10 by 37.1%, in comparison with the group 1. In group 3, the duration of swimming of rats increased by 47.7%. After orthostatic stress, a decrease in content was revealed: adrenaline 1.4 times, ACTH 8.2 times, corticosterone 1.4 times, IL-1β 1.5 times, IL-6 2.2 times, IL-10 in 1.2 times in relation to group number 2.

ТЭС-терапиявыносливостьстрессАКТГкортикостеронИЛ-1ИЛ-6ИЛ-10крысыtDCSendurancestressACTHcorticosteroneIL-1IL-6IL-10rats

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The authors declare that there are no conflicts of interest present.