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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">kurskvest</journal-id><journal-title-group><journal-title xml:lang="ru">Человек и его здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Humans and their health</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-5746</issn><issn pub-type="epub">1998-5754</issn><publisher><publisher-name>Kursk State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21626/vestnik/2017-3/16</article-id><article-id custom-type="elpub" pub-id-type="custom">kurskvest-253</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MEDICOBIOLOGICAL SCIENCES</subject></subj-group></article-categories><title-group><article-title>Изучение роли полиморфизма 279 G/A гена белка-переносчика эфиров холестерина в развитии острого небилиарного панкреатита</article-title><trans-title-group xml:lang="en"><trans-title>Studying the role of 279 G/A cholesteryl ester transfer protein gene polymorphism in the development of acute pancreatitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Животова</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhivotova</surname><given-names>G. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самгина</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Samgina</surname><given-names>T. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бушуева</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Bushueva</surname><given-names>O. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Назаренко</surname><given-names>П. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Nazarenko</surname><given-names>P. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полоников</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Polonikov</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Курский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kursk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2017</year></pub-date><volume>0</volume><issue>3</issue><fpage>95</fpage><lpage>97</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Животова Г.В., Самгина Т.А., Бушуева О.Ю., Назаренко П.М., Полоников А.В., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Животова Г.В., Самгина Т.А., Бушуева О.Ю., Назаренко П.М., Полоников А.В.</copyright-holder><copyright-holder xml:lang="en">Zhivotova G.V., Samgina T.A., Bushueva O.Y., Nazarenko P.M., Polonikov A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.kursk-vestnik.ru/jour/article/view/253">https://www.kursk-vestnik.ru/jour/article/view/253</self-uri><abstract><p>Целью исследования было изучение ассоциации полиморфизма 279 G/A гена СЕТР с риском развития острого небилиарного панкреатита в русской популяции. Образцы цельной крови были собраны у 281 больного острым панкреатитом и 200 здоровых. Генотипирование полиморфизма 279 G/A гена СЕТР выполнено с помощью метода ПЦР с дискриминацией аллелей с помощью TaqMan-зондов. В проведенном нами исследовании cтатистически значимых различий в частотах аллелей и генотипов полиморфизма 279 G/A гена СЕТР между группами здоровых индивидов и больных острым небилиарным панкреатитом не установлено. Нами был проведен стратифицированный анализ по полу, среди курящих пациентов - различий в группах больных и здоровых лиц получено не было. Поскольку среди факторов риска развития острого панкреатита особое место занимает злоупотребление алкогольными напитками, нами было изучено влияние объема напитка (до 199 г и 200 г и более чистого этанола в неделю), частота его употребления (2 и менее раз в месяц и более 1 раза в неделю) и длительность, т.е. алкогольный анамнез (до 10 лет и более 10 лет). Было обнаружено, что объем и частота приема алкогольных напитков не меняли общей картины ассоциации генотипов с риском развития острого небилиарного панкреатита.</p></abstract><trans-abstract xml:lang="en"><p>The aim of the study was to investigate the association of 279 G/A polymorphism of CETP gene with the risk for acute pancreatitis in Russian population. Whole blood samples were collected from 281 patients with acute pancreatitis and 200 healthy people. Polymorphism Genotyping 279 G/A CETP gene was accomplished by using PCR with allele discrimination with TaqMan-probes. There is no association of polymorphisms of 279 G/A CETP gene with the development of acute nonbiliary pancreatitis. We conducted a stratified analysis by sex, among smokers - no differences were found in the groups of patients and healthy individuals. Since alcohol abuse takes a particular place among the risk factors for acute pancreatitis, we studied the effect of the drink volume (up to 199g and 200g and&gt; pure ethanol per week), the frequency of its consumption (2 or less times a month and more than once a week), and duration (up to 10 years and more than 10 years). It was found that the volume and frequency of taking alcoholic beverages did not change the general picture of the association of genotypes with the risk for developing acute pancreatitis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый панкреатит</kwd><kwd>нарушение липидного обмена</kwd><kwd>полиморфизм 279 G/A гена СЕТР</kwd><kwd>acute pancreatitis</kwd><kwd>disturbance of lipid metabolism</kwd><kwd>polymorphism 279G/A CETP gene</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Горский В.А., Ковальчук Л.В., Агапов М.А. 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