kurskvestЧеловек и его здоровьеHumans and their health1998-57461998-5754Kursk State Medical University10.21626/vestnik/2017-1/15kurskvest-185Research ArticleМЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИMEDICOBIOLOGICAL SCIENCESПерспективы применения препаратов на основе мезенхимальных стволовых клеток в терапии пост-трансплантационных осложнений, связанных с иммунной несовместимостьюProspects of the therapy of post-transplantation complications caused by immune intolerance with mesenchymal stem cell-based productsБуруноваВ. В.BurunovaV. V.noemail@neicon.ruВасильевМ. П.VasilievM. P.noemail@neicon.ruЯрыгинН. В.YaryghinN. V.noemail@neicon.ruЯрыгинК. Н.YaryghinK. N.noemail@neicon.ruНИИ биомедицинской химии имени В.Н. ОреховичаРоссияInstitute of Biomedical ChemistryRussian FederationНПО «Стемма»РоссияStemma LtdRussian FederationМосковский государственный медико-стоматологический университет имени А.И. ЕвдокимоваРоссияA.I. Evdokimov Moscow State University of Medicine and DentistryRussian FederationНИИ биомедицинской химии имени В.Н. Ореховича; Научный центр акушерства, гинекологии и перинатологии имени академика В.И. КулаковаРоссияInstitute of Biomedical Chemistry; V.I. Kulakov Research Center of Obstetrics, Gynecology and PerinatologyRussian Federation201715122017018187Copyright © Бурунова В.В., Васильев М.П., Ярыгин Н.В., Ярыгин К.Н., 20172017Бурунова В.В., Васильев М.П., Ярыгин Н.В., Ярыгин К.Н.Burunova V.V., Vasiliev M.P., Yaryghin N.V., Yaryghin K.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.kursk-vestnik.ru/jour/article/view/185

Трансплантация мезенхимальных стволовых клеток (МСК), обладающих выраженной иммуносупрессорной активностью в условиях in vitro и in vivo, является безопасным и в некоторых случаях эффективным методом предотвращения и/или терапии иммунологических и некоторых других осложнений, возникающих после трансплантации органов и аллогенного костного мозга. Кроме того, экспериментальные и клинические данные указывают на возможность применения МСК для коррекции разнообразных иммунных нарушений и хронических воспалительных заболеваний. В настоящее время проводятся многочисленные клинические исследования по клеточной терапии пост-трансплантационных и других иммунологических проблем с использованием этих клеток.

Transplantation of mesenchymal stem cells (MSC), apparently possessing in vitro and in vivo immunosuppressive activity, is a safe and in some cases effective method of the prevention and/or therapy of immunological and other complications associated with organ and allogeneic bone marrow transplantation. Besides, experimental and clinical evidence suggests the possibility of the use of MSC to alleviate the symptoms of diverse immune defects and chronic inflammatory diseases. Numerous clinical trials in the field of MSC-based cell therapy of post-transplantation and other immunological problems are in progress.

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The authors declare that there are no conflicts of interest present.