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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">kurskvest</journal-id><journal-title-group><journal-title xml:lang="ru">Человек и его здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Humans and their health</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-5746</issn><issn pub-type="epub">1998-5754</issn><publisher><publisher-name>Kursk State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21626/vestnik/2026-2/04</article-id><article-id custom-type="edn" pub-id-type="custom">NIHFEV</article-id><article-id custom-type="elpub" pub-id-type="custom">kurskvest-1568</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Гипоксические тренировки в кардиологии: новые исследовательские подходы и клинические перспективы (систематический обзор)</article-title><trans-title-group xml:lang="en"><trans-title>Hypoxic training in cardiology: new research approaches and clinical prospects (systematic review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1163-4995</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данилова</surname><given-names>Анна Эдуардовна</given-names></name><name name-style="western" xml:lang="en"><surname>Danilova</surname><given-names>Anna E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант, МГУ, г. Москва.</p></bio><bio xml:lang="en"><p>Postgraduate student, MSU, Moscow, Russian Federation</p></bio><email xlink:type="simple">da.aniuta@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5670-167X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мацкеплишвили</surname><given-names>Симон Теймуразович</given-names></name><name name-style="western" xml:lang="en"><surname>Matskeplishvili</surname><given-names>Simon T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, профессор РАН, академик РАН, зам. директора по инновационной деятельности Университетской клиники, МГУ, врач-кардиолог, г. Москва</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences, Academician of the Russian Academy of Sciences, Deputy Director for Innovation Activities at the University Clinic, MSU, Moscow, Russian Federation</p></bio><email xlink:type="simple">simonmats@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный университет имени М.В. Ломоносова (МГУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Lomonosov Moscow State University (MSU)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>07</day><month>07</month><year>2026</year></pub-date><volume>29</volume><issue>2</issue><fpage>28</fpage><lpage>38</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Данилова А.Э., Мацкеплишвили С.Т., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Данилова А.Э., Мацкеплишвили С.Т.</copyright-holder><copyright-holder xml:lang="en">Danilova A.E., Matskeplishvili S.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.kursk-vestnik.ru/jour/article/view/1568">https://www.kursk-vestnik.ru/jour/article/view/1568</self-uri><abstract><p>Цель - определить подходы в изучении влияния гипоксических тренировок (нагрузок) на сердечно-сосудистую систему (ССС) у здоровых лиц, у пациентов с высокими кардиометаболическими рисками и при различных заболеваниях системы кровообращения, с последующей оценкой перспективности данного метода в качестве дополнительного профилактического и лечебно-реабилитационного подхода к лечению сердечно-сосудистых заболеваний. Материалы и методы. Осуществлен тематико-семантический поиск по базам данных и информационным системам: PubMed; Wiley; WoS; Google Scholar; eLIBRARY (до декабря 2025 года) для выявления рандомизированных контролируемых исследований с показаниями для включения в обзор, сравнивающие влияние хронических гипоксических и нормоксических тренировок на функцию сердечно-сосудистой системы у людей без сердечно-сосудистых заболеваний, с высокими кардиометаболическими факторами риска, и у пациентов с сердечно-сосудистыми заболеваниями. Систематический обзор осуществлен по рекомендациям PRISMA 2020. Глубина доступа не более 10 лет. Параметры исключения: удалены дублирующиеся записи и исследования на животных моделях. Результаты. Для включения в обзор были отобраны 8 рандомизированных клинических исследований (РКИ) с общим количеством участников 408 человек. Критерии поиска: взрослые люди старше 18 лет, клинические и лабораторно-инструментальные показатели в сравнении до/после: САДmax, ЧСС, АД в покое, ФВ. Показатели: Hb, SpO₂, уровень лактата в крови, общий холестерин (ОХ), холестерин ЛПНП, холестерин не-ЛПВП, триглицериды (ТГ), атерогенный индекс плазмы (АИП), липидный обмен и катехоламины.</p></abstract><trans-abstract xml:lang="en"><p>Objective - to identify approaches to studying the effects of hypoxic exercise (loads) on the cardiovascular system (CVS) in healthy individuals, in patients with high cardiometabolic risks, and in patients with various circulatory diseases, followed by an assessment of the potential of this method as an additional preventive and ther-apeutic-rehabilitative approach to the treatment of cardiovascular diseases. Materials and methods. A thematic and semantic search was conducted across the following databases and information systems: PubMed; Wiley; WoS; Google Scholar; eLIBRARY (until December 2025) to identify randomized controlled trials eligible for inclusion in the review, comparing the effects of chronic hypoxic and normoxic exercise on cardiovascular function in individuals without cardiovascular disease, with high cardiometabolic risk factors, and in patients with cardio-vascular disease. A systematic review was conducted according to the PRISMA 2020 guidelines. The review period was lim-ited to 10 years. Study identification. Exclusion criteria: duplicate records and studies using animal models were removed. Results. Eight randomized clinical trials (RCTs) with a total of 408 participants were selected for inclusion in the review. Search criteria: adults over 18 years of age, clinical and laboratory-instrumental parameters compared before/after: SBPmax, HR, resting blood pressure, EF. Indicators: Hb, SpO₂, blood lactate level, total cholesterol (TC), LDL cholesterol, non-HDL cholesterol, triglycerides (TG), atherogenic index of plasma (AIP), lipid metabolism, and catecholamines. Conclusion. Intermittent hypoxic and hypoxic-hyperoxic training represent a promising non-invasive method for addi-tional prevention and rehabilitation of cardiovascular diseases. Despite the encouraging results, large, multicenter, random-ized trials are needed to standardize protocols and confirm clinical efficacy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гипоксия</kwd><kwd>гипоксические тренировки</kwd><kwd>дозированная гипоксически-гипероксическая стимуляция</kwd><kwd>гипоксический-гипероксический парадокс</kwd><kwd>адаптивная медицина</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypoxia</kwd><kwd>hypoxic training</kwd><kwd>graded hypoxic-hyperoxic stimulation</kwd><kwd>hypoxic-hyperoxic paradox</kwd><kwd>adaptive medicine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Della Rocca Y., Fonticoli L., Rajan T.S., Trubiani O., Caputi S., Diomede F., Pizzicannella J., Marconi G.D. Hypoxia: molecular pathophysiological mechanisms in human diseases. J Physiol Biochem. 2022;78(4): 739-752. 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