<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">kurskvest</journal-id><journal-title-group><journal-title xml:lang="ru">Человек и его здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Humans and their health</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-5746</issn><issn pub-type="epub">1998-5754</issn><publisher><publisher-name>Kursk State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21626/vestnik/2026-1/06</article-id><article-id custom-type="edn" pub-id-type="custom">PGWSYU</article-id><article-id custom-type="elpub" pub-id-type="custom">kurskvest-1548</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАЦЕВТИЧЕСКИЕ НАУКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACEUTICAL SCIENCES</subject></subj-group></article-categories><title-group><article-title>Сравнительный анализ элементного профиля лекарственных трав Центрального Черноземья</article-title><trans-title-group xml:lang="en"><trans-title>Comparative analysis of elemental profile of medicinal herbs of the central Black Earth Region</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0766-3881</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дьякова</surname><given-names>Нина Алексеевна</given-names></name><name name-style="western" xml:lang="en"><surname>Dyakova</surname><given-names>Nina A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р фарм. наук, доцент, доцент кафедры фармацевтической технологии, ВГУ, г. Воронеж</p></bio><bio xml:lang="en"><p>Dr. Sci. (Pharm.), Associate Professor, Assistant Professor, Department of Pharmaceutical Technology, VSU, Voronezh, Russian Federation</p></bio><email xlink:type="simple">ninochka_v89@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Воронежский государственный университет (ВГУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh State University (VSU)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>19</day><month>05</month><year>2026</year></pub-date><volume>29</volume><issue>1</issue><fpage>53</fpage><lpage>62</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дьякова Н.А., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Дьякова Н.А.</copyright-holder><copyright-holder xml:lang="en">Dyakova N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.kursk-vestnik.ru/jour/article/view/1548">https://www.kursk-vestnik.ru/jour/article/view/1548</self-uri><abstract><p>Современные исследования подтверждают фундаментальную роль макро- и микроэлементов в формировании биологической активности лекарственных растений. Лекарственные растения, такие как горец птичий ( Polygonum aviculare L.), тысячелистник обыкновенный ( Achillea millefolium L.), полынь горькая ( Artemisia absinthium L.), пустырник пятилопастной ( Leonurus quinquelobatus Gilib.), широко используются как в традиционной, так и в народной медицине, при этом способны накапливать как жизненно необходимые, так и токсичные элементы. Цель - провести сравнительный элементный анализ лекарственных трав, заготовленных в природном фитоценозе Воронежской области. Материалы и методы. Травы растений заготовлены в фенофазу цветения на территории Воронежского государственного биосферного заповедника (экологически чистая зона). Параллельно с заготовкой трав были отобраны пробы почвы с верхнего горизонта (0-20 см). Методом масс-спектрометрии с индуктивно-связанной плазмой на спектрометре «ELAN-DRC» в соответствии с методическими указаниями МУК 4.1.1483-03 определяли элементный состав лекарственных трав и почвы после предварительной пробоподготовки методом кислотного и микроволнового разложения. Результаты. Количественно определено 59 элементов. Все изученные растения - активные аккумуляторы фосфора, калия, цинка и меди, что подчеркнуто их жизненно необходимым значением в физиологии растений. Тысячелистника обыкновенного и полыни горькой травы обладают высокой селективностью в минеральном питании - активно накапливают эссенциальные элементы и блокируют поступление остальных, что характеризует их метаболизм как высокоспециализированный. Горца птичьего и пустырника пятилопастного травы характеризуются более низкой селективностью в накоплении элементов, поглощают элементы более широким фронтом, что может быть адаптацией к нестабильным условиям или быстрому росту. Выявленные особенности к гипераккумуляции меди полынью горькой, кобальта и никеля пустырником пятилопастным, лития тысячелистником создают специфический минеральный профиль, который может модулировать активность ферментов, участвующих в синтезе алкалоидов, терпеноидов, флавоноидов, т.е. напрямую влиять на фармакологический потенциал сырья. Заключение. Проведенные исследования подтверждают богатый и безопасный макро- и микроэлементный профиль лекарственных трав естественного фитоценоза Центрального Черноземья. Однако, произрастая на одной и той же почве, лекарственные растения формируют абсолютно различный элементный состав надземной части, отражающий их адаптационные стратегии и потенциальные возможности для использования в медицине и нутрициологии.</p></abstract><trans-abstract xml:lang="en"><p>Modern studies confirm the fundamental role of macro- and microelements in the formation of biological activity of medicinal plants. Medicinal plants such as knotweed ( Polygonum aviculare L.), yarrow common ( Achillea millefolium L.), wormwood bitter ( Artemisia absinthium L.), motherwort five-lobed ( Leonurus quinquelobatus Gilib.) are widely used as traditional, and in traditional medicine, while being able to accumulate both vital and toxic elements. Objective - to conduct a comparative elemental analysis of medicinal herbs harvested in the natural phytocenosis of the Voronezh region. Materials and methods. Plant herbs are harvested in the phenophase of flowering on the territory of the Voronezh State Biosphere Reserve (environmentally friendly zone). In parallel with grass harvesting, soil samples were taken from the upper horizon (0-20 cm). The elemental composition of medicinal herbs and soil after preliminary sample preparation by the method of acid and microwave decomposition was determined by the method of mass spectrometry with inductively coupled plasma on the ELAN-DRC spectrometer in accordance with the methodological instructions of MUK 4.1.1483-03. Results. 59 elements were quantified. All studied plants are active batteries of phosphorus, potassium, zinc and copper, which is emphasized by their vital importance in plant physiology. Yarrow and wormwood of bitter grass have high selectivity in mineral nutrition - they actively accumulate essential elements, and block the flow of the rest, which characterizes their metabolism as highly specialized. Highlanders of bird and motherwort five-lobed grass are characterized by lower selectivity in the accumulation of elements, absorb elements with a wider front, which can be an adaptation to unstable conditions or rapid growth. The identified features for hyperaccumulation of copper by wormwood, cobalt and nickel motherwort, five-lobed, lithium yarrow create a specific mineral profile that can modulate the activity of enzymes involved in the synthesis of alkaloids, terpenoids, flavonoids, i.e. directly affect the pharmacological potential of the raw material. Conclusion. The studies carried out confirm the rich and safe macro- and microelement profile of medicinal herbs of natural phytocenosis of the Central Black Earth Region. However, growing on the same soil, medicinal plants form a completely different elemental composition of the aerial part, reflecting their adaptation strategies and potential opportunities for use in medicine and nutritionology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>полыни горькой трава</kwd><kwd>горца птичьего трава</kwd><kwd>пустырника пятилопастного трава</kwd><kwd>тысячелистника обыкновенного трава</kwd><kwd>микроэлементы</kwd><kwd>макроэлементы</kwd><kwd>коэффициенты биологического поглощения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>wormwood bitter grass</kwd><kwd>highlander bird grass</kwd><kwd>motherwort five-lobed grass</kwd><kwd>yarrow common grass</kwd><kwd>trace elements</kwd><kwd>macronutrients</kwd><kwd>biological absorption coefficients</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гравель И.В., Иващенко Н.В., Самылина И.А. Микроэлементный состав спазмолитического сбора и его компонентов. Фармация. 2011;(1):9-11. EDN: NDCUNN.</mixed-citation><mixed-citation xml:lang="en">Gravel' I.V., Ivashchenko N.V., Samylina I.A Microelement composition of spasmolytic collection and its components. Farmaciya. 2011;(1):9-11 (in Russ.). EDN: NDCUNN.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Афиногенов Ю.П., Бусыгина И.А., Гончаров Е.Г. Биогенные элементы и их физиологическая роль. Воронеж: Издательский Дом ВГУ; 2008. 143 с.</mixed-citation><mixed-citation xml:lang="en">Afinogenov Y.P., Busygina I.A., Goncharov E.G. Biogenic elements and their physiological role. Voronezh: Voronezh State University Publishing House; 2008. 143 p. (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Скальный А.В., Скальная М.Г., Киричук А.А., Тиньков А.А. Медицинская элементология. Москва: Наука; 2021.199 с</mixed-citation><mixed-citation xml:lang="en">Skal'nyj A.V., Skal'naya M.G., Kirichuk A.A., Tin'kov A.A. Medical elementology. Moscow: Nauka; 2021.199 р. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Dyakova N.A. Study into Peculiarities of Accumulation of Heavy Metals and Arsenic in Medicinal Plant Raw Materials of Synanthropic Flora of Voronezh Oblast.Russian Agricultural Sciences. 2025;51(5): 890-896. DOI: 10.3103/S1068367425701666</mixed-citation><mixed-citation xml:lang="en">Dyakova N.A. Study into Peculiarities of Accumulation of Heavy Metals and Arsenic in Medicinal Plant Raw Materials of Synanthropic Flora of Voronezh Oblast.Russian Agricultural Sciences. 2025;51(5): 890-896. DOI: 10.3103/S1068367425701666</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Pavlova Yu.A., Slivkin A.I., Dyakova N.A., Vervikina A.A. Study of Flavonoid Accumulation Patterns in Common Yarrow Herb of Synanthropic Flora in Rostov Oblast.Russian Agricultural Sciences. 2024;50(4):418-422. DOI: 10.3103/S1068367424700460</mixed-citation><mixed-citation xml:lang="en">Pavlova Yu.A., Slivkin A.I., Dyakova N.A., Vervikina A.A. Study of Flavonoid Accumulation Patterns in Common Yarrow Herb of Synanthropic Flora in Rostov Oblast.Russian Agricultural Sciences. 2024;50(4):418-422. DOI: 10.3103/S1068367424700460</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Dyakova N.A. Features of accumulation of macro- and trace elements by medicinal plant raw materials of Voronezh region. Pharmaceutical Chemistry Journal. 2023;56(11):1471-1476. DOI: 10.1007/s11094-023-02816-1. EDN: VBVYDG.</mixed-citation><mixed-citation xml:lang="en">Dyakova N.A. Features of accumulation of macro- and trace elements by medicinal plant raw materials of Voronezh region. Pharmaceutical Chemistry Journal. 2023;56(11):1471-1476. DOI: 10.1007/s11094-023-02816-1. EDN: VBVYDG.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Dyakova N.A. Features of extracting macroelements from medicinal plant raw materials into infusions and decoctions. Pharmaceutical Chemistry Journal. 2023;56(12):1633-1638. DOI: 10.1007/s11094-023-02838-9. EDN: MPXPVS.</mixed-citation><mixed-citation xml:lang="en">Dyakova N.A. Features of extracting macroelements from medicinal plant raw materials into infusions and decoctions. Pharmaceutical Chemistry Journal. 2023;56(12):1633-1638. DOI: 10.1007/s11094-023-02838-9. EDN: MPXPVS.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dyakova N.A. features of extraction of rare-earth elements from medicinal plant raw materials into infusions and decoctions. Pharmaceutical Chemistry Journal. 2023;57(5):688-693. DOI: 10.1007/s11094-023-02939-5. EDN: JOCHLI.</mixed-citation><mixed-citation xml:lang="en">Dyakova N.A. features of extraction of rare-earth elements from medicinal plant raw materials into infusions and decoctions. Pharmaceutical Chemistry Journal. 2023;57(5):688-693. DOI: 10.1007/s11094-023-02939-5. EDN: JOCHLI.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Куркин В.А. Фармакогнозия. Самара: Офорт; 2004. 1179 c.</mixed-citation><mixed-citation xml:lang="en">Kurkin VA Pharmacognosy. Samara: Ofort; 2004. 1179 p. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Регистр лекарственных средств России. URL: https://www.rlsnet.ru/</mixed-citation><mixed-citation xml:lang="en">Registr lekarstvennyh sredstv Rossii. (in Russ.). URL: https://www.rlsnet.ru/</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Государственная фармакопея Российской Федерации. Издание XIV. Том 4. Москва: ФЭМБ; 2018. 1883 с.</mixed-citation><mixed-citation xml:lang="en">State Pharmacopoeia of the Russian Federation. Edition XIV. Volume 4. Moscow: FEMB; 2018. 1883 p. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Fierascu I., Ungureanu C., Avramescu S.M., Fierascu R.C., Ortan A., Soare L.C., Paunescu A. In vitro antioxidant and antifungal properties of Achillea millefolium L. Rom Biotechnol Lett. 2015;20(4): 10626-10636.</mixed-citation><mixed-citation xml:lang="en">Fierascu I., Ungureanu C., Avramescu S.M., Fierascu R.C., Ortan A., Soare L.C., Paunescu A. In vitro antioxidant and antifungal properties of Achillea millefolium L. Rom Biotechnol Lett. 2015;20(4): 10626-10636.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Benedek B., Kopp B., Melzig M.F. Achillea millefolium L. - is the anti-inflammatory activity mediated by protease inhibition? J Ethnopharmacol. 2007;113(2):312-317. DOI: 10.1016/j.jep.2007.06.014.</mixed-citation><mixed-citation xml:lang="en">Benedek B., Kopp B., Melzig M.F. Achillea millefolium L. - is the anti-inflammatory activity mediated by protease inhibition? J Ethnopharmacol. 2007;113(2):312-317. DOI: 10.1016/j.jep.2007.06.014.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Moloudizargari M., Aghajanshakeri S., Javahery-pour S., Escort M., Velzi S., Velzi S. A current update on the phytopharmacological aspects of Achillea millefolium. J Pharm Biomed Sci. 2014;4(4):310-317.</mixed-citation><mixed-citation xml:lang="en">Moloudizargari M., Aghajanshakeri S., Javahery-pour S., Escort M., Velzi S., Velzi S. A current update on the phytopharmacological aspects of Achillea millefolium. J Pharm Biomed Sci. 2014;4(4):310-317.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Georgieva L, Gadjalova A, Mihaylova D, Pavlov A. Achillea millefolium L. - phytochemical profile and in vitro antioxidant activity.Int Food Res J. 2015;22(4):1347-1352.</mixed-citation><mixed-citation xml:lang="en">Georgieva L, Gadjalova A, Mihaylova D, Pavlov A. Achillea millefolium L. - phytochemical profile and in vitro antioxidant activity.Int Food Res J. 2015;22(4):1347-1352.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao HJ, Zou Q. Protective effects of exogenous antioxidants and phenolic compounds on photosynthesis of wheat leaves under high irradiance and oxidative stress. Photosynthetica. 2002;40(4):523-527. DOI: 10.1023/A:10212345678.</mixed-citation><mixed-citation xml:lang="en">Zhao HJ, Zou Q. Protective effects of exogenous antioxidants and phenolic compounds on photosynthesis of wheat leaves under high irradiance and oxidative stress. Photosynthetica. 2002;40(4):523-527. DOI: 10.1023/A:10212345678.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Saeidnia S., Gohari A.R., Mokhber-Dezfuli N., Kiuchi F. A review on phytochemistry and medicinal properties of the genus Achillea. DARU J Pharm Sci. 2011;19(3):173-186. DOI:10.1007/s00000-011-0123.</mixed-citation><mixed-citation xml:lang="en">Saeidnia S., Gohari A.R., Mokhber-Dezfuli N., Kiuchi F. A review on phytochemistry and medicinal properties of the genus Achillea. DARU J Pharm Sci. 2011;19(3):173-186. DOI:10.1007/s00000-011-0123.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Pavlova Y.A., Slivkin A.I., Dyakova N.A., Vervikina A.A. Study of flavonoid accumulation patterns in common yarrow herb of synanthropic flora in Rostov oblast.Russ Agric Sci. 2024;50(4):418-422. DOI: 10.3103/S1068367424700460.</mixed-citation><mixed-citation xml:lang="en">Pavlova Y.A., Slivkin A.I., Dyakova N.A., Vervikina A.A. Study of flavonoid accumulation patterns in common yarrow herb of synanthropic flora in Rostov oblast.Russ Agric Sci. 2024;50(4):418-422. DOI: 10.3103/S1068367424700460.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Falconieri D., Piras A., Porcedda S., Marongiu B., Gonçalves M.J., Cabral C., Cavaleiro C., Salgueiro L. Chemical composition and biological activity of the volatile extracts of Achillea millefolium. Nat Prod Commun. 2011;6(10):1527-1530. DOI: 10.1177/1934578X1100601030</mixed-citation><mixed-citation xml:lang="en">Falconieri D., Piras A., Porcedda S., Marongiu B., Gonçalves M.J., Cabral C., Cavaleiro C., Salgueiro L. Chemical composition and biological activity of the volatile extracts of Achillea millefolium. Nat Prod Commun. 2011;6(10):1527-1530. DOI: 10.1177/1934578X1100601030</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bączek K.A., Kosakowska O.L., Przybył J.L., Kuźma P., Ejdys M., Obiedziński M., Węglarz Z.Intraspecific variability of yarrow (Achillea millefolium L. s.l.) in respect of developmental and chemical traits. Herba Pol. 2015;61(3):37-52. DOI: 10.1515/HEPO-2015-0021.</mixed-citation><mixed-citation xml:lang="en">Bączek K.A., Kosakowska O.L., Przybył J.L., Kuźma P., Ejdys M., Obiedziński M., Węglarz Z.Intraspecific variability of yarrow (Achillea millefolium L. s.l.) in respect of developmental and chemical traits. Herba Pol. 2015;61(3):37-52. DOI: 10.1515/HEPO-2015-0021.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Dyakova N.A., Korenskaya I.M., Slivkin A.I., Gaponov S.P. Features of accumulation and qualitative composition of essential oil of common yarrow herb from Voronezh region. Pharm Chem J. 2022;56(9):1226-1233. DOI: 10.1007/s11094-022-02779-9. EDN: SLVGRZ.</mixed-citation><mixed-citation xml:lang="en">Dyakova N.A., Korenskaya I.M., Slivkin A.I., Gaponov S.P. Features of accumulation and qualitative composition of essential oil of common yarrow herb from Voronezh region. Pharm Chem J. 2022;56(9):1226-1233. DOI: 10.1007/s11094-022-02779-9. EDN: SLVGRZ.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Vitalini S., Beretta G., Iriti M., Orsenigo S., Basilico N., Dall'Acqua S., Iorizzi M., Fico G. Phenolic compounds from Achillea millefolium L. and their bioactivity. Acta Biochim Pol. 2011;58(2):203-209.</mixed-citation><mixed-citation xml:lang="en">Vitalini S., Beretta G., Iriti M., Orsenigo S., Basilico N., Dall'Acqua S., Iorizzi M., Fico G. Phenolic compounds from Achillea millefolium L. and their bioactivity. Acta Biochim Pol. 2011;58(2):203-209.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Pavlova Yu.A., Dyakova N.A., Vervikina A.A., Slivkin A.I. Features of the accumulation of flavonoids in medicinal plant raw materials of the synanthropic flora of Rostov region. Pharmaceutical Chemistry Journal. 2024;58(4):666-671. DOI: 10.1007/s11094-024-03192-0. EDN: MIQMDA.</mixed-citation><mixed-citation xml:lang="en">Pavlova Yu.A., Dyakova N.A., Vervikina A.A., Slivkin A.I. Features of the accumulation of flavonoids in medicinal plant raw materials of the synanthropic flora of Rostov region. Pharmaceutical Chemistry Journal. 2024;58(4):666-671. DOI: 10.1007/s11094-024-03192-0. EDN: MIQMDA.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Талыкова Н.М., Дворникова Л.Г., Турецкова В.Ф. Изучение свободных и связанных сахаров в горца птичьего траве, произрастающего в Алтайском крае. Вестник Воронежского государственного университета. Серия: Химия. Биология. Фармация. 2022;(3):120-125.EDN: GKQAEL.</mixed-citation><mixed-citation xml:lang="en">Talykova N.M., Dvornikova L.G., Turetskova V.F. Study of free and bound sugars in knotgrass herb growing in the Altai region. Vestn Voronezh Gos Univ Ser Khim Biol Farm. 2022;(3): 120-125. (in Russ.). EDN: GKQAEL.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Талыкова Н.М., Турецкова В.Ф., Кудрикова Л.Е. Горец птичий флоры Алтая как перспективный источник фенолокислот. Вестник Воронежского государственного университета. Серия: Химия. Биология. Фармация. 2025;(1):100-106.EDN: LMJBAT.</mixed-citation><mixed-citation xml:lang="en">Talykova N.M., Turetskova V.F., Kudrikova L.E. Knotweed of Altai flora as a promising source of phenolic acids. Vestn Voronezh Gos Univ Ser Khim Biol Farm. 2025;(1):100-106. (in Russ.). EDN: LMJBAT.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Monzote L., Pinon A., Scull R., Setzer W.N. Chemistry and leishmanicidal activity of the essential oil from Artemisia absinthium from Cuba. Nat Prod Commun. 2014;9(12):1799-1804. DOI: 10.1177/1934578X1400901234.</mixed-citation><mixed-citation xml:lang="en">Monzote L., Pinon A., Scull R., Setzer W.N. Chemistry and leishmanicidal activity of the essential oil from Artemisia absinthium from Cuba. Nat Prod Commun. 2014;9(12):1799-1804. DOI: 10.1177/1934578X1400901234.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Baghban Taraghdari S., Nematy M., Mazidi M., Kamgar M., Soukhtanloo M., Hosseini M., Rakhshandeh H., Norouzy A., et al. The effect of hydro-alcoholic extract of Artemisia absinthium on appetite in male rats. Avicenna J Phytomed. 2015;5(2):78-83.</mixed-citation><mixed-citation xml:lang="en">Baghban Taraghdari S., Nematy M., Mazidi M., Kamgar M., Soukhtanloo M., Hosseini M., Rakhshandeh H., Norouzy A., et al. The effect of hydro-alcoholic extract of Artemisia absinthium on appetite in male rats. Avicenna J Phytomed. 2015;5(2):78-83.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Basiri Z., Zeraati F., Esna-Ashari F., Mohammadi F., Razzaghi K., Araghchian M., Moradkhani S. Topical Effects of Artemisia Absinthium Ointment and Liniment in Comparison with Piroxicam Gel in Patients with Knee Joint Osteoarthritis: A Randomized Double-Blind Controlled Trial. Iran J Med Sci. 2017;42(6):524-531.</mixed-citation><mixed-citation xml:lang="en">Basiri Z., Zeraati F., Esna-Ashari F., Mohammadi F., Razzaghi K., Araghchian M., Moradkhani S. Topical Effects of Artemisia Absinthium Ointment and Liniment in Comparison with Piroxicam Gel in Patients with Knee Joint Osteoarthritis: A Randomized Double-Blind Controlled Trial. Iran J Med Sci. 2017;42(6):524-531.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Beshay E.V.N. Therapeutic efficacy of Artemisia absinthium against Hymenolepis nana: in vitro and in vivo studies in comparison with the anthelmintic praziquantel. J Helminthol. 2018;92(3):298-308. DOI: 10.1017/S0022149X17000529</mixed-citation><mixed-citation xml:lang="en">Beshay E.V.N. Therapeutic efficacy of Artemisia absinthium against Hymenolepis nana: in vitro and in vivo studies in comparison with the anthelmintic praziquantel. J Helminthol. 2018;92(3):298-308. DOI: 10.1017/S0022149X17000529</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Bora K.S., Sharma A. Neuroprotective effect of Artemisia absinthium L. on focal ischemia and reperfusion-induced cerebral injury. J Ethnopharmacol. 2010;129(3):403-409. DOI: 10.1016/j.jep.2010.04.015.</mixed-citation><mixed-citation xml:lang="en">Bora K.S., Sharma A. Neuroprotective effect of Artemisia absinthium L. on focal ischemia and reperfusion-induced cerebral injury. J Ethnopharmacol. 2010;129(3):403-409. DOI: 10.1016/j.jep.2010.04.015.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Marciniuk P., Gawrońska B., Marciniuk J., Joachimiak A.J. Taxonomic individuality of Leonurus cardiaca and Leonurus quinquelobatus in view of morphological and molecular studies. Plant Syst Evol. 2014;300(2):255-261. DOI: 10.1007/s00606-013-0878-6.</mixed-citation><mixed-citation xml:lang="en">Marciniuk P., Gawrońska B., Marciniuk J., Joachimiak A.J. Taxonomic individuality of Leonurus cardiaca and Leonurus quinquelobatus in view of morphological and molecular studies. Plant Syst Evol. 2014;300(2):255-261. DOI: 10.1007/s00606-013-0878-6.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Rácz G., Rácz-Kotilla E. Sedative and antihypertensive activity of Leonurus quinquelobatus. Planta Med. 1989;55(1):97. DOI:10.1055/s-2006-961847.</mixed-citation><mixed-citation xml:lang="en">Rácz G., Rácz-Kotilla E. Sedative and antihypertensive activity of Leonurus quinquelobatus. Planta Med. 1989;55(1):97. DOI:10.1055/s-2006-961847.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmed F., Islam M.A., Rahman M.M. Antibacterial activity of Leonurus sibiricus aerial parts. Fitoterapia. 2006;77(4):316-317. DOI: 10.1016/j.fitote.2006.03.001.</mixed-citation><mixed-citation xml:lang="en">Ahmed F., Islam M.A., Rahman M.M. Antibacterial activity of Leonurus sibiricus aerial parts. Fitoterapia. 2006;77(4):316-317. DOI: 10.1016/j.fitote.2006.03.001.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Wojtyniak K., Szymański M., Matławska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res. 2012;27(8):1115-1120. DOI: 10.1002/ptr.4850.</mixed-citation><mixed-citation xml:lang="en">Wojtyniak K., Szymański M., Matławska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res. 2012;27(8):1115-1120. DOI: 10.1002/ptr.4850.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ritter M., Melichar K., Strahler S., Kuchta K., Schulte J., Sartiani L., Cerbai E., Mugelli A., et al. Cardiac and electrophysiological effects of primary and refined extracts from Leonurus cardiaca L. (Ph.Eur.). Planta Med. 2010;76(6):572-582. DOI: 10.1055/s-0029-1240602.</mixed-citation><mixed-citation xml:lang="en">Ritter M., Melichar K., Strahler S., Kuchta K., Schulte J., Sartiani L., Cerbai E., Mugelli A., et al. Cardiac and electrophysiological effects of primary and refined extracts from Leonurus cardiaca L. (Ph.Eur.). Planta Med. 2010;76(6):572-582. DOI: 10.1055/s-0029-1240602.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
