kurskvestЧеловек и его здоровьеHumans and their health1998-57461998-5754Kursk State Medical UniversityNPRNEGkurskvest-1491Research ArticleМЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИMEDICOBIOLOGICAL SCIENCESNIS как диагностический маркер трижды негативного рака молочной железы ENG NIS as a diagnostic marker for triple-negative breast cancerNIS as a diagnostic marker for triple-negative breast cancerhttps://orcid.org/0000-0001-8447-2600ДемяшкинГригорий АлександровичDemyashkinGrigory A.

д-р мед. наук, зав. отделом цифровой онкоморфологии, МНИОИ им. П.А. Герцена, г. Москва.

Dr. Sci. (Med.), Head of Department of Digital Oncomorphology, P.A. Herzen MORI, Moscow, Russian Federation

dr.dga@mail.ruhttps://orcid.org/0000-0002-5833-3401ГузикАнастасия АндреевнаGuzikAnastasia A.

соискатель, МНИОИ им. П.А. Герцена, г. Москва

Applicant, P.A. Herzen MORI, Moscow, Russian Federation

https://orcid.org/0009-0006-3746-3924БелокопытовДмитрий ВячеславовичBelokopytovDmitry V.

лаборант-исследователь отдела цифровой онкоморфологии, МНИОИ им. П.А. Герцена, г. Москва

Research laboratory assistant at the Department of Digital Oncomorphology, P.A. Herzen MORI, Moscow, Russian Federation

https://orcid.org/0000-0003-4775-3299ЛюбченкоЛюдмила НиколаевнаLyubchenkoLyudmila N.

д-р мед. наук, зав. отделом молекулярной генетики и клеточных технологий, МНИОИ им. П.А. Герцена, г. Москва

Dr. Sci. (Med.), Head of Department of Molecular Genetics and Cellular Technologies, P.A. Herzen MORI, Moscow, Russian Federation

https://orcid.org/0000-0003-4449-7859ЦибулевскийАлександр ЮрьевичTsibulevskyAlexander Yu.

д-р мед. наук, профессор, гл. науч. сотрудник лаборатории патоморфологии, НИКИ ПДХ им. Ю.Е. Вельтищева, г. Москва

Dr. Sci. (Med.), Professor, Chief Scientific Officer. an employee of the Laboratory of Pathomorphology, Yu.E. Veltishchev RCIPPS, Moscow, Russian Federation

auts77@gmail.comhttps://orcid.org/0009-0002-0840-2226ГригорянДиана МиграновнаGrigoryanDiana M.

ассистент, МНИОИ им. П.А. Герцена, г. Москва

Research laboratory assistant at the Department of Digital Oncomorphology, P.A. Herzen MORI, Moscow, Russian Federation

Московский научно-исследовательский онкологический институт им. П.А. Герцена - филиал «НМИЦ радиологии» (МНИОИ им. П.А. Герцена)РоссияP.A. Herzen Moscow Oncology Research Institute - branch of the National Medical Research Radiological Center (P.A. Herzen MORI)Russian FederationНаучно-исследовательский клинический институт педиатрии и детской хирургии имени академика Ю.Е. Вельтищева РНИМУ им. Н.И. Пирогова (НИКИ ПДХ им. Ю.Е. Вельтищева)РоссияYu.E. Veltishchev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University (Yu.E. Veltishchev RCIPPS)Russian FederationМосковский научно-исследовательский онкологический институт им. П.А. Герцена - филиал «НМИЦ радиологии» (МНИОИ им. П.А. Герцена) Россия, 125284, г. Москва, 2-й Боткинский проезд, д. 3РоссияP.A. Herzen Moscow Oncology Research Institute - branch of the National Medical Research Radiological Center (P.A. Herzen MORI)Russian Federation2025050220262847583Copyright © Демяшкин Г.А., Гузик А.А., Белокопытов Д.В., Любченко Л.Н., Цибулевский А.Ю., Григорян Д.М., 20262026Демяшкин Г.А., Гузик А.А., Белокопытов Д.В., Любченко Л.Н., Цибулевский А.Ю., Григорян Д.М.Demyashkin G.A., Guzik A.A., Belokopytov D.V., Lyubchenko L.N., Tsibulevsky A.Y., Grigoryan D.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.kursk-vestnik.ru/jour/article/view/1491

Диагностика трижды негативного рака молочной железы (ТНРМЖ) затруднена из-за низкой дифференцировки и отсутствия надежных маркеров. Существующие маркеры (Mammaglobin, GATA-3) обладают недостаточной чувствительностью и/или специфичностью для дифференциальной диагностики ТНРМЖ, особенно при метастатическом характере процесса.

Цель - сравнить экспрессию NIS (натрий-йод симпортер), Mammaglobin и GATA-3 в ТНРМЖ для оценки рациональности и эффективности применения NIS в качестве диагностического маркера.

Материалы и методы

Материалы и методы. Ретроспективное исследование (n=161) биопсийных образцов ТНРМЖ с применением иммуногистохимического анализа (IHC) для оценки экспрессии NIS, Mammaglobin и GATA-3.

Результаты

Результаты. NIS показал наибольшую чувствительность (70,0%) по сравнению с Mammaglobin (31,0%) и GATA-3 (63,7%). Комбинированное использование NIS и GATA-3 позволило достичь чувствительности в 82,5%.

Заключение

Заключение. NIS является перспективным маркером для диагностики ТНРМЖ, особенно в сочетании с GATA-3.

Diagnosis of triple-negative breast cancer (TNBC) is challenging due to its low differentiation and the lack of reliable markers. Existing markers (Mammaglobin, GATA-3) possess insufficient sensitivity and/or specificity for the differential diagnosis of TNBC, especially in metastatic disease.

Objective - to compare the expression of NIS (sodium-iodide symporter), Mammaglobin, and GATA-3 in TNBC to evaluate the rationality and effectiveness of using NIS as a diagnostic marker.

Materials and methods

Materials and methods. Retrospective study (n=161) of TNBC biopsy samples using immunohistochemical analysis (IHC) to assess the expression of NIS, Mammaglobin, and GATA-3.

Results

Results. NIS showed the highest sensitivity (70.0%) compared to Mammaglobin (31.0%) and GATA-3 (63.7%). Combined use of NIS and GATA-3 achieved a sensitivity of 82.5%.

Conclusion

Conclusion. NIS is a promising marker for the diagnosis of TNBC, especially in combination with GATA-3.

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The authors declare that there are no conflicts of interest present.