kurskvestЧеловек и его здоровьеHumans and their health1998-57461998-5754Kursk State Medical University10.21626/vestnik/2024-3/11VPSOPCkurskvest-1343Research ArticleМЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИMEDICOBIOLOGICAL SCIENCESПатофизиологическая роль обмена меди и цинка в канцерогенезе и опухолевой прогрессии - пути к новым возможностям терапии и прогнозированияPathophysiological role of copper and zinc metabolism in carcino-genesis and tumor progression - ways to new possibilities of therapy and prognosishttps://orcid.org/0000-0003-3841-4164ХвостовойВладимир ВладимировичKhvostovoyVladimir V.

канд. мед. наук, доцент, зав. кафедрой онкологии, КГМУ, г. Курск; врач-онколог отделения опухолей кожи, костей и мягких тканей, КОНКЦ, г. Курск

Cand. Sci. (Med.), Head of the Department of Oncology, KSMU, Kursk, Russian Federation; Oncologist at the Department of Skin, Bone and Soft Tissue Tumors, KCRCC, Kursk, Russian Federation

vvkhvostovoi@yandex.ruhttps://orcid.org/0000-0002-9681-672XСтаноевичИрина ВасильевнаStanoevichIrina V.

д-р мед. наук, доцент, профессор кафедры онкологии, КГМУ, г. Курск; врач акушер-гинеколог отдела эндокринной хирургии Института клинической эндокринологии, НМИЦ эндокринологии, г. Москва

Dr. Sci. (Med.), Professor, Professor at the Department of Oncology, KSMU, Kursk, Russian Federation; Obstetrician-gynecologist, ERC, Moscow, Russian Federation

2849143@gmail.comhttps://orcid.org/0009-0007-3848-7562ГончаровИван МихайловичGoncharovIvan M.

студент, КГМУ, г. Курск

Student, KSMU, Kursk, Russian Federation

goncharovim@kursksmu.nethttps://orcid.org/0000-0001-7910-5611ПетроченкоДмитрий ВладимировичPetrochenkoDmitry V.

врач-онколог круглосуточного стационара противоопухолевой лекарственной терапии, КОНКЦ, г. Курск

oncologist at the round-the-clock hospital for antitumor drug therapy, KCRCC, Kursk, Russian Federation

petrochenko.dima@yandex.ruhttps://orcid.org/0000-0002-5316-571XБыкановаАнна МихайловнаBykanovaAnna M.

Курский государственный медицинский университет (КГМУ);Курский онкологический научно-клинический центр им. Г.Е. Островерхова (КОНКЦ)

Assistant at Department of Oncology, Kursk State Medical University (Kursk, Russia); oncologist at the round-the-clock hospital for antitumor drug therapy, KSMU, Kursk, Russian Federation

Курский государственный медицинский университет (КГМУ); Курский онкологический научно-клинический центр им. Г.Е. Островерхова (КОНКЦ)РоссияKursk State Medical University (KSMU); G.E. Ostroverkhov Kursk Cancer Research and Clinical Center (KCRCC)Russian FederationКурский государственный медицинский университет (КГМУ); Национальный медицинский исследовательский центр эндокринологии (НМИЦ эндокринологии)РоссияKursk State Medical University (KSMU); Endocrinology Research Center (ERC)Russian FederationКурский государственный медицинский университет (КГМУ)РоссияKursk State Medical University (KSMU)Russian FederationКурский онкологический научно-клинический центр им. Г.Е. Островерхова (КОНКЦ)РоссияG.E. Ostroverkhov Kursk Cancer Research and Clinical Center (KCRCC)Russian FederationKursk State Medical University (KSMU); G.E. Ostroverkhov Kursk Cancer Research and Clinical Center (KCRCC)Russian Federation20242910202427398108Copyright © Хвостовой В.В., Станоевич И.В., Гончаров И.М., Петроченко Д.В., Быканова А.М., 20242024Хвостовой В.В., Станоевич И.В., Гончаров И.М., Петроченко Д.В., Быканова А.М.Khvostovoy V.V., Stanoevich I.V., Goncharov I.M., Petrochenko D.V., Bykanova A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.kursk-vestnik.ru/jour/article/view/1343

Цель - провести систематический анализ данных, имеющихся в современной литературе, о патофизиологической роли обмена меди и цинка в канцерогенезе и опухолевой прогрессии. Материал и методы. При подготовке обзора был проведен анализ публикаций информационных баз биомедицинской литературы Scopus (307), PubMed (378), Web of Science (104), eLibrary.ru (219). Для получения полнотекстовых документов использованы электронные ресурсы PubMed Central (PMC), Science Direct, Research Gate, eLibrary.ru. Результаты. Медь и цинк выполняют значительную патофизиологическую роль в канцерогенезе, нередко являясь функциональными антагонистами друг друга, но иногда и синергистами в неопластических процессах. Будущие перспективы исследования препаратов, способных избирательно влиять на интратуморальную концентрацию данных элементов, создают привлекательные дополнения к лекарственной терапии. На данный момент все потенциальные препараты находятся на ранних этапах исследований, однако результаты при отдельных нозологиях уже являются многообещающими. Заключение. Необходимо продолжать комплексные исследования по использованию ионов меди и цинка в качестве терапевтических мишеней, что может в будущем стать альтернативой высокотоксичной классической химиотерапии. Специфичность и чувствительность маркеров на основе анализа концентрации меди и цинка в сыворотке крови и их соотношение остаются на достаточно низком уровне. Это может быть полезным инструментом для оценки в динамике уровня меди и цинка в процессе противоопухолевой лекарственной терапии различных опухолей. Кроме этого, наше понимание патофизиологической роли этих элементов позволяет создать полную картину молекулярных альтераций в каждом конкретном случае.

Objectivе - to carry out a systematic analysis of the data available in the modern literature on the pathophysiological role of copper and zinc metabolism in carcinogenesis and tumor progression. Materials and methods. In preparing the review, the publications of the biomedical literature information databases Scopus (307), PubMed (378), Web of Science (104) were analyzed, eLibrary.ru (219). To obtain full-text documents, the electronic resources PubMed Central (PMC), Science Direct, Research Gate, eLibrary.ru. Results. Copper and zinc play a significant pathophysiological role in carcinogenesis, often being functional antagonists of each other, but sometimes synergists in neoplastic processes. Future prospects for the study of drugs capable of selectively influencing the intrathumoral concentration of these elements create attractive additions to drug therapy. At the moment, all potential drugs are in the early stages of research, but the results for individual nosologies are already promising. Conclusion. It is necessary to continue comprehensive research on the use of copper and zinc ions as therapeutic targets, which may in the future become an alternative to highly toxic classical chemotherapy. The specificity and sensitivity of markers based on the analysis of the concentration of copper and zinc in blood serum and their ratio remains at a fairly low level. This can be a useful tool for assessing the dynamics of copper and zinc levels in the process of antitumor drug therapy of various tumors. In addition, our understanding of the pathophysiological role of these elements allows us to create a complete picture of molecular alterations in each case.

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The authors declare that there are no conflicts of interest present.