kurskvestЧеловек и его здоровьеHumans and their health1998-57461998-5754Kursk State Medical University10.21626/vestnik/2023-3/03SLHMDMkurskvest-1210Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEПотенциальные возможности биоинженерных технологий и клеточной имплантации при герниоэндо-протезировании (обзорная статья)Potential possibilities of bioengineering technologies and cellular implantation in hernioendoprosthetics (review article)https://orcid.org/0000-0002-2069-7701ЛазаренкоВиктор АнатольевичLazarenkoViktor A.

д-р мед. наук., профессор, заслуженный врач РФ, заслуженный деятель науки РФ, ректор, зав. кафедрой хирургических болезней ИНО, КГМУ, г. Курск

Dr. Sci. (Med.), Professor, Honoured Doctor of Russia, Honoured Scientist of Russia, Rector, Head of the Department of Surgical Diseases of ICE, KSMU, Kursk, Russian Federation

lazarenkova@kursksmu.nethttps://orcid.org/0000-0003-4408-961XИвановИлья СергеевичIvanovIlya S.

д-р мед. наук., профессор, зав. кафедрой хирургических болезней № 1, КГМУ, г. Курск

Dr. Sci. (Med.), Professor, Head of Department of Surgical Diseases No. 1, KSMU, Kursk, Russian Federation

ivanov.is@mail.ruhttps://orcid.org/0000-0003-0876-0656УшановАлександр АлександровичUshanovAlexander A.

очный аспирант кафедры хирургических болезней № 1, КГМУ, г. Курск

Full-time postgraduate student at the Department of Surgical Diseases No. 1, KSMU, Kursk, Russian Federation

ushanovaa@kursksmu.nethttps://orcid.org/0000-0003-3835-0594МишинаЕкатерина СергеевнаMishinaEkaterina S.

канд. мед. наук, доцент, доцент кафедры гистологии, эмбриологии, цитологии, КГМУ, г. Курск

Cand. Sci. (Med.), Associate Professor, Associate Professor at the Department of Histology, Embryology, Cytology, KSMU, Kursk, Russian Federation

mishinaes@kursksmu.nethttps://orcid.org/0000-0003-0566-1476ОбъедковЕвгений ГеннадьевичObedkovEvgenij G.

канд. мед. наук, доцент кафедры хирургических болезней № 1, КГМУ, г. Курск

Cand. Sci. (Med.), Associate Professor at the Department of Surgical Diseases No. 1, KSMU, Kursk, Russian Federation

obiedkoveg@kursksmu.nethttps://orcid.org/0000-0002-5158-3424АлексеевАлександр ГеннадьевичAlexeevAlexander G.

канд. мед. наук, доцент, директор медицинского института, РОСБИОТЕХ, г. Москва

Cand. Sci. (Med.), Associate Professor, Director, RBU, Moscow, Russian Federation

alekseevag@mgupp.ruhttps://orcid.org/0000-0001-8374-6200КостинВиталий СтаниславовичKostinVitaly S.

студент, КГМУ, г. Курск

student, KSMU, Kursk, Russian Federation

Курский государственный медицинский университет (КГМУ)РоссияKursk State Medical University (KSMU)Russian FederationРоссийский биотехнологический университет (РОСБИОТЕХ)РоссияRussian Biotechnological Universirt (ROSBIOTECH University)Russian Federation2023301120232631928Copyright © Лазаренко В.А., Иванов И.С., Ушанов А.А., Мишина Е.С., Объедков Е.Г., Алексеев А.Г., Костин В.С., 20232023Лазаренко В.А., Иванов И.С., Ушанов А.А., Мишина Е.С., Объедков Е.Г., Алексеев А.Г., Костин В.С.Lazarenko V.A., Ivanov I.S., Ushanov A.A., Mishina E.S., Obedkov E.G., Alexeev A.G., Kostin V.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.kursk-vestnik.ru/jour/article/view/1210

Цель - установить наиболее эффективный путь совершенствования герниопластики согласно данным литературы. Материалы и методы. Был проведен анализ научной литературы по реферативным базам PubMed, Scopus, РИНЦ, а также с помощью реферативного программного обеспечения Mendeley. В обзоре представлены данные, отражающие тенденции в рассматриваемой области за последнее десятилетие, согласно мнению авторов. Результаты. Применение клеточных технологий может утвердить позиции рассасывающихся герниопротезов за счет улучшения качества соединительной ткани послеоперационного рубца и понижения возможности послеоперационных осложнений. В практике лечения ран используются препараты коллагена и нативные фибробласты, о применении которых имеются положительные данные, говорящие о высоком потенциале такого вида терапии. Применение клеточных технологий смогло бы утвердить позиции рассасывающихся герниопротезов за счет улучшения качества соединительной ткани послеоперационного рубца и понижения возможности послеоперационных осложнений. Заключение. Клеточная имплантация при герниоэндопротезировании - один из наиболее перспективных путей решения проблемы превентивного лечения послеоперационных грыж передней брюшной стенки. Применение фибробластов для потенцирования пролиферативной активности в операционной ране позволит улучшить качественные характеристики соединительной ткани и обеспечит более выгодный долгосрочный эффект вмешательства, а также предупредить рецидивы грыж.

The aim of this review is to determine the most effective way to improve hernioplasty in accordance with the literature data. Materials and methods. The scientific literature was analyzed using PubMed, Scopus, RINC, and Mendeley abstracting software. The review presents data reflecting the trends in the field under consideration over the last decade, according to the authors' opinion. Results. The use of cellular technologies can confirm the position of absorbable hernioprostheses by improving the quality of connective tissue of the postoperative scar and reducing the likelihood of postoperative complications. In the practice of wound treatment, collagen preparations and native fibroblasts are used, the use of which has positive data indicating a high potential of this type of therapy. The application of cell technologies could confirm the position of resorbable hernioprostheses by improving the quality of connective tissue of the postoperative scar and reducing the possibility of postoperative complications. Conclusion. Cellular implantation during hernioendoprosthetics is one of the most promising ways to solve the problem of preventive treatment of postoperative hernias of the anterior abdominal wall. The use of fibroblasts to enhance proliferative activity in the surgical wound will improve the quality characteristics of connective tissue and provide a more favorable long-term effect of the intervention, as well as prevent recurrence of hernias.

грыжигерниоэндопротезированиеклеточные технологиифибробластыполимерные сеткибиосовместимостьherniashernioendoprostheticscellular technologiesfibroblastspolymer meshesbiocompatibilityReferencesКириенко А.И., Шевцов Ю.Н., Никишков А.С., Селиверстов Е.И., Андрияшкин А.В., Татаринцев А.М., Золотухин И.А. Распространенность грыж передней брюшной стенки: результаты популяционного исследования. Хирургия. 2016;(8):61-66. DOI: 10.17116/hirurgia2016861-66. EDN: WKENAP.Kiriyenko A.I., Shevtsov Yu.N., Nikishkov A.S., Seliverstov Ye.I., Andriyashkin A.V., Tatarintsev A.M., Zolotukhin I.A. Incidence of abdominal wall hernias: the results of population study. Khirurgiya. 2016;(8):61-66 (in Russ.). DOI: 10.17116/hirurgia2016861-66. EDN: WKENAP.Кириенко А.И., Никишков А.С., Селиверстов Е.И., Андрияшкин А.В. Эпидемиология грыж передней брюшной стенки. Эндоскопическая хирургия. 2016;22(4):55-60. DOI: 10.17116/endoskop201622455-60. EDN: YGGJDL.Kirienko A.I., Nikishkov A.S., Seliverstov E.I., Andriyashkin A.V. Epidemiology of abdominal wall hernias. Endoskopicheskaya khirurgiya. 2016;22(4):55-60 (in Russ.). DOI: 10.17116/endoskop201622455-60. EDN: YGGJDL.Helgstrand F. National results after ventral hernia repair. Dan Med J. 2016;63(7):B5258.Helgstrand F. National results after ventral hernia repair. Dan Med J. 2016;63(7):B5258.Винник Ю.С., Чайкин А.А., Назарьянц Ю.А., Петрушко С.И. Современный взгляд на проблему лечения больных с послеоперационными вентральными грыжами. Сибирское медицинское обозрение. 2014;6(90):5-13. EDN: THEHCP.Vinnik Y.S., Chaykin A.A., Nazaryants Y.A., Petrushko S.I. Contemporary view on the problem of treatment the patients with postoperative ventral hernias. Sibirskoye meditsinskoye obozreniye. 2014;6(90):5-13 (in Russ.). EDN: THEHCP.Лазаренко В.А., Иванов И.С., Ушанов А.А., Мишина Е.С., Объедков Е.Г., Костин В.С. Грыжа или грыжевой дефект? Экспериментальные модели на лабораторных животных в герниологии. Инновационная медицина Кубани. 2023;8(3):114-120. DOI: 10.35401/2541-9897-2023-26-3-114-120. EDN: FYWKFC.Lazarenko V.A., Ivanov I.S., Ushanov A.A., Mishina E.S., Obedkov E.G., Kostin V.S. Hernia or hernia defect? Experimental models on laboratory animals in herniology. Innovative Medicine of Kuban. 2023;8(3):114-120 (in Russ.). DOI: 10.35401/2541-9897-2023-26-3-114-120. EDN: FYWKFC.Сажин А.В., Лобан К.М., Ивахов Г.Б., Петухов В.А., Глаголев Н.С., Андрияшкин А.В., Ахмедов Р.Р. Современные концепции хирургии вентральных грыж. Новости хирургии. 2020;28(6):714-729. DOI: 10.18484/2305-0047.2020.6.714. EDN: VMKIBL.Sazhin А.V., Loban К.M., Ivakhov G.B., Petukhov V.A., Glagolev N.S., Andriyashkin A.V., Akhmedov R.R. Current Concepts of Ventral Hernia Surgery. Novosti Khirurgii. 2020;28(6):714-729 (in Russ.). DOI: 10.18484/2305-0047.2020.6.714. EDN: VMKIBL.Thankam F.G., Palanikumar G., Fitzgibbons R.J., Agrawal D.K. Molecular Mechanisms and Potential Therapeutic Targets in Incisional Hernia. J Surg Res. 2019;236:134-143. DOI: 10.1016/j.jss.2018.11.037.Thankam F.G., Palanikumar G., Fitzgibbons R.J., Agrawal D.K. Molecular Mechanisms and Potential Therapeutic Targets in Incisional Hernia. J Surg Res. 2019;236:134-143. DOI: 10.1016/j.jss.2018.11.037.Davidson S., Coles M., Thomas T., Kollias G., Ludewig B., Turley S., Brenner M., Buckley C.D. Fibroblasts as immune regulators in infection, inflammation and cancer. Nat Rev Immunol. 2021;21(11): 704-717. DOI: 10.1038/s41577-021-00540-z.Davidson S., Coles M., Thomas T., Kollias G., Ludewig B., Turley S., Brenner M., Buckley C.D. Fibroblasts as immune regulators in infection, inflammation and cancer. Nat Rev Immunol. 2021;21(11): 704-717. DOI: 10.1038/s41577-021-00540-z.Miroshnichenko S., Timofeeva V., Permykova E., Ershov S., Kiryukhantsev-Korneev P., Dvořaková E., Shtansky D.V., Zajíčková L., et al. Plasma-Coated Polycaprolactone Nanofibers with Covalently Bonded Platelet-Rich Plasma Enhance Adhesion and Growth of Human Fibroblasts. Nanomaterials (Basel). 2019;9(4):637. DOI: 10.3390/nano9040637.Miroshnichenko S., Timofeeva V., Permykova E., Ershov S., Kiryukhantsev-Korneev P., Dvořaková E., Shtansky D.V., Zajíčková L., et al. Plasma-Coated Polycaprolactone Nanofibers with Covalently Bonded Platelet-Rich Plasma Enhance Adhesion and Growth of Human Fibroblasts. Nanomaterials (Basel). 2019;9(4):637. DOI: 10.3390/nano9040637.Sadava E.E., Krpata D.M., Gao Y., Rosen M.J., Novitsky Y.W. Wound healing process and mediators: Implications for modulations for hernia repair and mesh integration. J Biomed Mater Res A. 2014;102(1): 295-302. DOI: 10.1002/jbm.a.34676.Sadava E.E., Krpata D.M., Gao Y., Rosen M.J., Novitsky Y.W. Wound healing process and mediators: Implications for modulations for hernia repair and mesh integration. J Biomed Mater Res A. 2014;102(1): 295-302. DOI: 10.1002/jbm.a.34676.Thankam F.G., Larsen N.K., Varghese A., Bui T.N., Reilly M., Fitzgibbons R.J., Agrawal D.K. Biomarkers and heterogeneous fibroblast phenotype associated with incisional hernia. Mol Cell Biochem. 2021;476(9):3353-3363. DOI: 10.1007/s11010-021-04166-6.Thankam F.G., Larsen N.K., Varghese A., Bui T.N., Reilly M., Fitzgibbons R.J., Agrawal D.K. Biomarkers and heterogeneous fibroblast phenotype associated with incisional hernia. Mol Cell Biochem. 2021;476(9):3353-3363. DOI: 10.1007/s11010-021-04166-6.Koike Y., Yozaki M., Utani A., Murota H. Fibroblast growth factor 2 accelerates the epithelial-mesenchymal transition in keratinocytes during wound healing process. Sci Rep. 2020;10(1):18545. DOI: 10.1038/s41598-020-75584-7.Koike Y., Yozaki M., Utani A., Murota H. Fibroblast growth factor 2 accelerates the epithelial-mesenchymal transition in keratinocytes during wound healing process. Sci Rep. 2020;10(1):18545. DOI: 10.1038/s41598-020-75584-7.Hu L., Wang J., Zhou X., Xiong Z., Zhao J., Yu R., Huang F., Zhang H., Chen L. Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Sci Rep. 2016;6:32993. DOI: 10.1038/srep32993.Hu L., Wang J., Zhou X., Xiong Z., Zhao J., Yu R., Huang F., Zhang H., Chen L. Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Sci Rep. 2016;6:32993. DOI: 10.1038/srep32993.Petter-Puchner A.H., Fortelny R.H., Gruber-Blum S., Redl H., Dietz U. The future of stem cell therapy in hernia and abdominal wall repair. Hernia. 2015;19(1):25-31. DOI: 10.1007/s10029-014-1288-7.Petter-Puchner A.H., Fortelny R.H., Gruber-Blum S., Redl H., Dietz U. The future of stem cell therapy in hernia and abdominal wall repair. Hernia. 2015;19(1):25-31. DOI: 10.1007/s10029-014-1288-7.Darby I.A., Laverdet B., Bonté F., Desmoulière A. Fibroblasts and myofibroblasts in wound healing. Clin Cosmet Investig Dermatol. 2014;7:301-311. DOI: 10.2147/CCID.S50046.Darby I.A., Laverdet B., Bonté F., Desmoulière A. Fibroblasts and myofibroblasts in wound healing. Clin Cosmet Investig Dermatol. 2014;7:301-311. DOI: 10.2147/CCID.S50046.desJardins-Park H.E., Foster D.S., Longaker M.T. Fibroblasts and wound healing: an update. Regen Med. 2018;13(5):491-495. DOI: 10.2217/rme-2018-0073.desJardins-Park H.E., Foster D.S., Longaker M.T. Fibroblasts and wound healing: an update. Regen Med. 2018;13(5):491-495. DOI: 10.2217/rme-2018-0073.Olczyk P., Mencner Ł., Komosinska-Vassev K. The role of the extracellular matrix components in cutaneous wound healing. Biomed Res Int.;2014:747584. DOI: 10.1155/2014/747584.Olczyk P., Mencner Ł., Komosinska-Vassev K. The role of the extracellular matrix components in cutaneous wound healing. Biomed Res Int.;2014:747584. DOI: 10.1155/2014/747584.Bainbridge P. Wound healing and the role of fibroblasts. J Wound Care. 2013;22(8):407-412. DOI: 10.12968/jowc.2013.22.8.407.Bainbridge P. Wound healing and the role of fibroblasts. J Wound Care. 2013;22(8):407-412. DOI: 10.12968/jowc.2013.22.8.407.Stejskalová A., Almquist B.D. Using biomaterials to rewire the process of wound repair. Biomater Sci. 2017;5(8):1421-1434. DOI: 10.1039/c7bm00295e.Stejskalová A., Almquist B.D. Using biomaterials to rewire the process of wound repair. Biomater Sci. 2017;5(8):1421-1434. DOI: 10.1039/c7bm00295e.Serrano-Aroca Á., Pous-Serrano S. Prosthetic meshes for hernia repair: State of art, classification, biomaterials, antimicrobial approaches, and fabrication methods. J Biomed Mater Res A. 2021;109(12): 2695-2719. DOI: 10.1002/jbm.a.37238.Serrano-Aroca Á., Pous-Serrano S. Prosthetic meshes for hernia repair: State of art, classification, biomaterials, antimicrobial approaches, and fabrication methods. J Biomed Mater Res A. 2021;109(12): 2695-2719. DOI: 10.1002/jbm.a.37238.López-Cano M., Quiles M.T., Pereira J.A., Armengol-Carrasco M., Arbós Vía M.A.Complex Abdominal Wall Hernia Repair in Contaminated Surgical Fields: Factors Affecting the Choice of Prosthesis. Am Surg. 2017;83(6):583-590.López-Cano M., Quiles M.T., Pereira J.A., Armengol-Carrasco M., Arbós Vía M.A.Complex Abdominal Wall Hernia Repair in Contaminated Surgical Fields: Factors Affecting the Choice of Prosthesis. Am Surg. 2017;83(6):583-590.Usher F.C., Wallace S.A. Tissue reaction to plastics; a comparison of nylon, orlon, dacron, teflon, and marlex. AMA Arch Surg. 1958;76(6):997-999.Usher F.C., Wallace S.A. Tissue reaction to plastics; a comparison of nylon, orlon, dacron, teflon, and marlex. AMA Arch Surg. 1958;76(6):997-999.Saiding Q., Chen Y., Wang J., Pereira C.L., Sarmento B., Cui W., Chen X. Abdominal wall hernia repair: from prosthetic meshes to smart materials. Mater Today Bio. 2023;21:100691. DOI: 10.1016/j.mtbio.2023.100691.Saiding Q., Chen Y., Wang J., Pereira C.L., Sarmento B., Cui W., Chen X. Abdominal wall hernia repair: from prosthetic meshes to smart materials. Mater Today Bio. 2023;21:100691. DOI: 10.1016/j.mtbio.2023.100691.Faylona J.M. Evolution of ventral hernia repair. Asian journal of endoscopic surgery. 2017;10(3):252-258. DOI: 10.1111/ases.12392Faylona J.M. Evolution of ventral hernia repair. Asian journal of endoscopic surgery. 2017;10(3):252-258. DOI: 10.1111/ases.12392Mayet N., Choonara Y.E., Kumar P., Tomar L.K., Tyagi C., Du Toit.LC., Pillay V. A comprehensive review of advanced biopolymeric wound healing systems. J Pharm Sci. 2014;103(8):2211-2230. DOI: 10.1002/jps.24068.Mayet N., Choonara Y.E., Kumar P., Tomar L.K., Tyagi C., Du Toit.LC., Pillay V. A comprehensive review of advanced biopolymeric wound healing systems. J Pharm Sci. 2014;103(8):2211-2230. DOI: 10.1002/jps.24068.See C.W., Kim T., Zhu D. Hernia mesh and hernia repair: a review. Engineered Regeneration. 2020;(1):19-33. DOI: 10.1016/j.engreg.2020.05.002See C.W., Kim T., Zhu D. Hernia mesh and hernia repair: a review. Engineered Regeneration. 2020;(1):19-33. DOI: 10.1016/j.engreg.2020.05.002Mori da Cunha M.G.M.C., Arts B., Hympanova L., Rynkevic R., Mackova K., Bosman A.W., Dankers P.Y.W., Deprest J. Functional supramolecular bioactivated electrospun mesh improves tissue ingrowth in experimental abdominal wall reconstruction in rats. Acta Biomater. 2020;106:82-91. DOI: 10.1016/j.actbio.2020.01.041.Mori da Cunha M.G.M.C., Arts B., Hympanova L., Rynkevic R., Mackova K., Bosman A.W., Dankers P.Y.W., Deprest J. Functional supramolecular bioactivated electrospun mesh improves tissue ingrowth in experimental abdominal wall reconstruction in rats. Acta Biomater. 2020;106:82-91. DOI: 10.1016/j.actbio.2020.01.041.Zhang Z., Zhu L., Hu W., Dai J., Ren P., Shao X., Xiong B., Zhang T., Ji Z. Polypropylene mesh combined with electrospun poly (L-lactic acid) membrane in situ releasing sirolimus and its anti-adhesion efficiency in rat hernia repair. Colloids Surf B Biointerfaces. 2022;218:112772. DOI: 10.1016/j.colsurfb.2022.112772.Zhang Z., Zhu L., Hu W., Dai J., Ren P., Shao X., Xiong B., Zhang T., Ji Z. Polypropylene mesh combined with electrospun poly (L-lactic acid) membrane in situ releasing sirolimus and its anti-adhesion efficiency in rat hernia repair. Colloids Surf B Biointerfaces. 2022;218:112772. DOI: 10.1016/j.colsurfb.2022.112772.Hympanova L., Mori da Cunha M.G.M.C., Rynkevic R., Zündel M., Gallego M.R., Vange J., Callewaert G., Urbankova I., et al. Physiologic musculofascial compliance following reinforcement with electrospun polycaprolactone-ureidopyrimidinone mesh in a rat model. J Mech Behav Biomed Mater. 2017;74:349-357. DOI: 10.1016/j.jmbbm.2017.06.032.Hympanova L., Mori da Cunha M.G.M.C., Rynkevic R., Zündel M., Gallego M.R., Vange J., Callewaert G., Urbankova I., et al. Physiologic musculofascial compliance following reinforcement with electrospun polycaprolactone-ureidopyrimidinone mesh in a rat model. J Mech Behav Biomed Mater. 2017;74:349-357. DOI: 10.1016/j.jmbbm.2017.06.032.Cornwell K.G., Zhang F., Lineaweaver W. Bovine fetal collagen reinforcement in a small animal model of hernia with component repair. J Surg Res. 2016;201(2):416-424. DOI: 10.1016/j.jss.2015.10.049.Cornwell K.G., Zhang F., Lineaweaver W. Bovine fetal collagen reinforcement in a small animal model of hernia with component repair. J Surg Res. 2016;201(2):416-424. DOI: 10.1016/j.jss.2015.10.049.Dydak K., Junka A., Nowacki G., Paleczny J., Szymczyk-Ziółkowska P., Górzyńska A., Aniołek O., Bartoszewicz M. In Vitro Cytotoxicity, Colonisation by Fibroblasts and Antimicrobial Properties of Surgical Meshes Coated with Bacterial Cellulose.Int J Mol Sci. 2022;23(9):4835. DOI: 10.3390/ijms23094835.Dydak K., Junka A., Nowacki G., Paleczny J., Szymczyk-Ziółkowska P., Górzyńska A., Aniołek O., Bartoszewicz M. In Vitro Cytotoxicity, Colonisation by Fibroblasts and Antimicrobial Properties of Surgical Meshes Coated with Bacterial Cellulose.Int J Mol Sci. 2022;23(9):4835. DOI: 10.3390/ijms23094835.Hansen S.G., Taskin M.B., Chen M., Wogensen L., Vinge Nygaard J., Axelsen S.M. Electrospun nanofiber mesh with fibroblast growth factor and stem cells for pelvic floor repair. J Biomed Mater Res B Appl Biomater. 2020;108(1):48-55. DOI: 10.1002/jbm.b.34364.Hansen S.G., Taskin M.B., Chen M., Wogensen L., Vinge Nygaard J., Axelsen S.M. Electrospun nanofiber mesh with fibroblast growth factor and stem cells for pelvic floor repair. J Biomed Mater Res B Appl Biomater. 2020;108(1):48-55. DOI: 10.1002/jbm.b.34364.Rosen M.J., Krpata D.M., Petro C.C., Carbonell A., Warren J., Poulose B.K., Costanzo A., Tu C., et al. Biologic vs Synthetic Mesh for Single-stage Repair of Contaminated Ventral Hernias: A Randomized Clinical Trial. JAMA Surg. 2022;157(4):293-301. DOI: 10.1001/jamasurg.2021.6902.Rosen M.J., Krpata D.M., Petro C.C., Carbonell A., Warren J., Poulose B.K., Costanzo A., Tu C., et al. Biologic vs Synthetic Mesh for Single-stage Repair of Contaminated Ventral Hernias: A Randomized Clinical Trial. JAMA Surg. 2022;157(4):293-301. DOI: 10.1001/jamasurg.2021.6902.Kanitra J.J., Hess A.L., Haan P.S., Anderson C.I., Kavuturu S. Hernia recurrence and infection rate in elective complex abdominal wall repair using biologic mesh. BMC Surg. 2019;19(1):174. DOI: 10.1186/s12893-019-0640-3.Kanitra J.J., Hess A.L., Haan P.S., Anderson C.I., Kavuturu S. Hernia recurrence and infection rate in elective complex abdominal wall repair using biologic mesh. BMC Surg. 2019;19(1):174. DOI: 10.1186/s12893-019-0640-3.Taibi A., Derbal S., Durand Fontanier S., Christou N., Fredon F., Bouvier S., Fabre A., Rivaille T., et al. Implantation of biologic mesh in ventral hernia repair-does it make sense? Surg Endosc. 2021;35(2):702-709. DOI: 10.1007/s00464-020-07435-5.Taibi A., Derbal S., Durand Fontanier S., Christou N., Fredon F., Bouvier S., Fabre A., Rivaille T., et al. Implantation of biologic mesh in ventral hernia repair-does it make sense? Surg Endosc. 2021;35(2):702-709. DOI: 10.1007/s00464-020-07435-5.Kaufmann R., Isemer F.E., Strey C.W., Jeekel J., Lange J.F., Woeste G. Non-cross-linked biological mesh in complex abdominal wall hernia: a cohort study. Langenbecks Arch Surg. 2020;405(3):345-352. DOI: 10.1007/s00423-020-01881-4.Kaufmann R., Isemer F.E., Strey C.W., Jeekel J., Lange J.F., Woeste G. Non-cross-linked biological mesh in complex abdominal wall hernia: a cohort study. Langenbecks Arch Surg. 2020;405(3):345-352. DOI: 10.1007/s00423-020-01881-4.Morales-Conde S., Hernández-Granados P., Tallón-Aguilar L., Verdaguer-Tremolosa M., López-Cano M. Ventral hernia repair in high-risk patients and contaminated fields using a single mesh: proportional meta-analysis. Hernia. 2022;26(6):1459-1471. DOI: 10.1007/s10029-022-02668-w.Morales-Conde S., Hernández-Granados P., Tallón-Aguilar L., Verdaguer-Tremolosa M., López-Cano M. Ventral hernia repair in high-risk patients and contaminated fields using a single mesh: proportional meta-analysis. Hernia. 2022;26(6):1459-1471. DOI: 10.1007/s10029-022-02668-w.Olavarria O.A., Bernardi K., Dhanani N.H., Lyons N.B., Harvin J.A., Millas S.G., Ko T.C., Kao L.S., et al. Synthetic versus Biologic Mesh for Complex Open Ventral Hernia Repair: A Pilot Randomized Controlled Trial. Surg Infect (Larchmt). 2021;22(5):496-503. DOI: 10.1089/sur.2020.166.Olavarria O.A., Bernardi K., Dhanani N.H., Lyons N.B., Harvin J.A., Millas S.G., Ko T.C., Kao L.S., et al. Synthetic versus Biologic Mesh for Complex Open Ventral Hernia Repair: A Pilot Randomized Controlled Trial. Surg Infect (Larchmt). 2021;22(5):496-503. DOI: 10.1089/sur.2020.166.Sivaraj D., Henn D., Fischer K.S., Kim T.S., Black C.K., Lin J.Q., Barrera J.A., Leeolou M.C., et al. Reinforced Biologic Mesh Reduces Postoperative Complications Compared to Biologic Mesh after Ventral Hernia Repair. Plast Reconstr Surg Glob Open. 2022;10(2):e4083. DOI: 10.1097/GOX.0000000000004083.Sivaraj D., Henn D., Fischer K.S., Kim T.S., Black C.K., Lin J.Q., Barrera J.A., Leeolou M.C., et al. Reinforced Biologic Mesh Reduces Postoperative Complications Compared to Biologic Mesh after Ventral Hernia Repair. Plast Reconstr Surg Glob Open. 2022;10(2):e4083. DOI: 10.1097/GOX.0000000000004083.Fan Z., Zhao X., Li J., Ji R., Shi Y. Cell-based therapies for reinforcing the treatment efficacy of meshes in abdominal wall hernias A systematic review and meta-analysis. Asian J Surg. 2022;45(9):1667-1677. DOI: 10.1016/j.asjsur.2021.09.019.Fan Z., Zhao X., Li J., Ji R., Shi Y. Cell-based therapies for reinforcing the treatment efficacy of meshes in abdominal wall hernias A systematic review and meta-analysis. Asian J Surg. 2022;45(9):1667-1677. DOI: 10.1016/j.asjsur.2021.09.019.Богдан В.Г., Швед И.А. Трансплантация мезенхимальных стволовых клеток из жировой ткани при пластике моделированного дефекта брюшной стенки: морфологические особенности тканевой реакции. Военная медицина. 2013;(1):94-100Bogdan V.G., Shved I.A. Transplantation of mesenchymal stem cells from adipose tissue during plastic surgery of a simulated abdominal wall defect: morphological features of tissue reaction. Military medicine. 2013;(1):94-100 (in Russ.). EDN: RQEAST.Mohsina A., Kumar N., Sharma A.K., Mishra B., Mathew D.D., Remya V., Shrivastava S., Negi M., et al. Bioengineered acellular dermal matrices for the repair of abdominal wall defects in rats. Hernia. 2015;19(2):219-229. DOI: 10.1007/s10029-014-1308-7.Mohsina A., Kumar N., Sharma A.K., Mishra B., Mathew D.D., Remya V., Shrivastava S., Negi M., et al. Bioengineered acellular dermal matrices for the repair of abdominal wall defects in rats. Hernia. 2015;19(2):219-229. DOI: 10.1007/s10029-014-1308-7.Mohsina A., Kumar N., Sharma A.K., Shrivastava S., Mathew D.D., Remya V., Sonal, Maiti S.K., et al. Polypropylene mesh seeded with fibroblasts: A new approach for the repair of abdominal wall defects in rats. Tissue Cell. 2017;49(3):383-392. DOI: 10.1016/j.tice.2017.04.004.Mohsina A., Kumar N., Sharma A.K., Shrivastava S., Mathew D.D., Remya V., Sonal, Maiti S.K., et al. Polypropylene mesh seeded with fibroblasts: A new approach for the repair of abdominal wall defects in rats. Tissue Cell. 2017;49(3):383-392. DOI: 10.1016/j.tice.2017.04.004.Guillaume O., Park J., Monforte X., Gruber-Blum S., Redl H., Petter-Puchner A., Teuschl A.H. Fabrication of silk mesh with enhanced cytocompatibility: preliminary in vitro investigation toward cell-based therapy for hernia repair. J Mater Sci Mater Med. 2016;27(2):37. DOI: 10.1007/s10856-015-5648-3.Guillaume O., Park J., Monforte X., Gruber-Blum S., Redl H., Petter-Puchner A., Teuschl A.H. Fabrication of silk mesh with enhanced cytocompatibility: preliminary in vitro investigation toward cell-based therapy for hernia repair. J Mater Sci Mater Med. 2016;27(2):37. DOI: 10.1007/s10856-015-5648-3.Vozzi F., Nardo T., Guerrazzi I., Domenici C., Rocchicciol, S., Cecchettini A., Comelli L., Vozzi G., et al.Integration of biomechanical and biological characterization in the development of porous poly (caprolactone)-based membranes for abdominal wall hernia treatment.International Journal of Polymer Science. 2018;1-15. DOI: 10.1155/2018/2450176.Vozzi F., Nardo T., Guerrazzi I., Domenici C., Rocchicciol, S., Cecchettini A., Comelli L., Vozzi G., et al.Integration of biomechanical and biological characterization in the development of porous poly (caprolactone)-based membranes for abdominal wall hernia treatment.International Journal of Polymer Science. 2018;1-15. DOI: 10.1155/2018/2450176.See C.W., Kim T., Zhu D. Hernia mesh and hernia repair: a review. Engineered Regeneration. 2020;1: 19-33. DOI: 10.1016/j.engreg.2020.05.002.See C.W., Kim T., Zhu D. Hernia mesh and hernia repair: a review. Engineered Regeneration. 2020;1: 19-33. DOI: 10.1016/j.engreg.2020.05.002.Bondre I.L., Holihan J.L., Askenasy E.P., Greenberg J.A., Keith J.N., Martindale R.G., Roth J.S., Liang M.K., et al. Suture, synthetic, or biologic in contaminated ventral hernia repair. J Surg Res. 2016;200(2):488-494. DOI: 10.1016/j.jss.2015.09.007.Bondre I.L., Holihan J.L., Askenasy E.P., Greenberg J.A., Keith J.N., Martindale R.G., Roth J.S., Liang M.K., et al. Suture, synthetic, or biologic in contaminated ventral hernia repair. J Surg Res. 2016;200(2):488-494. DOI: 10.1016/j.jss.2015.09.007.

The authors declare that there are no conflicts of interest present.