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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">kurskvest</journal-id><journal-title-group><journal-title xml:lang="ru">Человек и его здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Humans and their health</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-5746</issn><issn pub-type="epub">1998-5754</issn><publisher><publisher-name>Kursk State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21626/vestnik/2022-4/02</article-id><article-id custom-type="elpub" pub-id-type="custom">kurskvest-1108</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Патогенетические механизмы повреждения сердечно-сосудистой системы при новой коронавирусной инфекции (COVID-19)</article-title><trans-title-group xml:lang="en"><trans-title>Pathogenetic mechanisms of damage to the cardiovascular system in new coronavirus infection (COVID-19)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5672-9341</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степченко</surname><given-names>Александр Александрович</given-names></name><name name-style="western" xml:lang="en"><surname>Stepchenko</surname><given-names>Alexander A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, доцент, профессор кафедры внутренних болезней ИНО, КГМУ, г. Курск</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Associate Professor, Professor at the Department of Internal Diseases of ICE, KSMU, Kursk, Russian Federation.</p></bio><email xlink:type="simple">therapy-fpo@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7450-7048</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гнездилова</surname><given-names>Евгения Сергеевна</given-names></name><name name-style="western" xml:lang="en"><surname>Gnezdilova</surname><given-names>Evgeniya S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заочный аспирант кафедры внутренних болезней Института непрерывного образования, КГМУ, г. Курск</p></bio><bio xml:lang="en"><p>Part-time Post-Graduate Student at the Department of Internal Diseases of ICE, KSMU, Kursk, Russian Federation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7105-7501</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степченко</surname><given-names>Марина Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Stepchenko</surname><given-names>Marina A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, доцент, профессор кафедры внутренних болезней №1, КГМУ, г. Курск</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Associate Professor, Professor at the Department of Internal Medicine No 1, KSMU, Kursk, Russian Federation</p></bio><email xlink:type="simple">clemenso@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7770-428X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тригуб</surname><given-names>Анастасия Владимировна</given-names></name><name name-style="western" xml:lang="en"><surname>Trigub</surname><given-names>Anastasia V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры внутренних болезней ИНО, КГМУ, г. Курск</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Assistant lecturer at the Department of Internal Diseases of ICE, KSMU, Kursk, Russian Federation</p></bio><email xlink:type="simple">anastasiavtrigub@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Курский государственный медицинский университет (КГМУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kursk State Medical University (KSMU)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2022</year></pub-date><volume>25</volume><issue>4</issue><fpage>11</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Степченко А.А., Гнездилова Е.С., Степченко М.А., Тригуб А.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Степченко А.А., Гнездилова Е.С., Степченко М.А., Тригуб А.В.</copyright-holder><copyright-holder xml:lang="en">Stepchenko A.A., Gnezdilova E.S., Stepchenko M.A., Trigub A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.kursk-vestnik.ru/jour/article/view/1108">https://www.kursk-vestnik.ru/jour/article/view/1108</self-uri><abstract><p>Цель: оценить результаты клинических исследований, посвященных изучению патогенетических механизмов повреждения миокарда и коронарных артерий у пациентов, перенесших новую коронавирусную инфекцию (COVID-19). Материалы и методы. Поиск научной информации проводили в отечественной (E-Library) и зарубежных базах данных (PubMed, Scopus, Oxford University Press, Springer, Web of Science Core Collection). Результаты. Патология сердечно-сосудистой системы широко распро-странена у пациентов, переболевших коронавирусной инфекцию: начиная с артериальной и легочной гипертензии, снижения толерантности к физической нагрузке с нестабильной ЧСС и АД, развития и прогрессирования атеросклероза, тромбоангиопатии, коронарной эндотелиальной дисфункции с развитием ишемической болезни сердца, аневризматическим расширением коронарных артерий и аорты, развитием миокардита и различных аритмий и заканчивая внезапной сердечной смертью. Патология сердечно-сосудистой системы развивается как у пациентов, перенесших тяжелое течение COVID-19, так и пациентов, проходивших лечение амбулаторно и даже у людей с отсутствием явных симптомов коронавирусной инфекции. Заключение. Пациенты в остром периоде коронавирусной инфекции при возникновении патологии со стороны сердца и сосудов, имеют некоторое преимущество - они, как правило, находятся под наблюдением. У пациентов, перенесших COVID-19 в легкой форме, в дальнейшем необходимо применять классические подходы для выявления лиц с субклиническими проявлениями сердечно-сосудистой патологии (факторы сердечно-сосудистого риска, соответствующая симптоматика, повышение тропонина в острый период инфекции) и своевременного назначения терапии в соответствии с клиническими рекомендациями. Следует подчеркнуть, что любые вмешательства должны быть основаны на патофизиологических механизмах long-COVID.</p></abstract><trans-abstract xml:lang="en"><p>Objective of the study: to analyze and systematize the results of fundamental and clinical studies of recent years devoted to the study of the pathogenetic mechanisms of myocardial and coronary artery damage in patients who have undergone a new coronavirus infection (COVID-19). Materials and methods. The search for scientific information was carried out in domestic (E-Library) and foreign databases (PubMed, Scopus, Oxford University Press, Springer, Web of Science Core Collection). Results. It has been shown that the variety of cardiovascular system pathologies after a coronavirus infection is quite wide: heart failure, arrhythmias, sudden cardiac death, coronary heart disease, coronary microvascular dysfunction with coronary insufficiency, formation of coronary artery and aortic aneurysms, hypertension, labile heart rate and BP response to physical activity, acceleration of atherogenesis processes, venous and arterial thromboembolism. Cardiovascular pathology can develop both in patients after severe and moderate COVID-19, and in oligosymptomatic and asymptomatic individuals. Patients with emerging cardiovascular pathology in the acute period of coronavirus infection, as a rule, are under observation and in this situation changes in therapeutic strategies occur faster. Patients with newly diagnosed cardiovascular pathology after suffering COVID-19 need special attention and timely assessment to exclude or confirm cardiovascular complications. Conclusion. The presented data suggest that the tactics and strategy for the management of cardiovascular diseases in the post-covid period should be based on the timely and modern diagnosis of the onset or decompensation of cardiovascular pathology, competent, in accordance with current recommendations management of cardiovascular pathology with emphasis on the use of therapeutic interventions affecting the pathophysiological mechanisms of long covid.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Covid-19</kwd><kwd>коронавирусная инфекция</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>миокардит</kwd><kwd>коронарные артерии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Covid-19</kwd><kwd>coronavirus infection</kwd><kwd>coronary heart disease</kwd><kwd>myocarditis</kwd><kwd>coronary arteries</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Z., Mc Googan J. 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