kurskvestЧеловек и его здоровьеHumans and their health1998-57461998-5754Kursk State Medical University10.21626/vestnik/2022-2/10kurskvest-1033Research ArticleФАРМАЦЕВТИЧЕСКИЕ НАУКИPHARMACEUTICAL SCIENCESРастительные стеролы и станолы, снижающие уровень холестерина липопротеинов низкой плотностиPlant sterols and stanols that lower low-density lipoprotein cholesterolhttps://orcid.org/0000-0002-3104-7974ФедотоваВиктория ВладимировнаFedotovaVictoria V.

канд. фарм. наук, доцент кафедры фармакогнозии, ботаники и технологии фитопрепаратов, ПМФИ - филиал ВолгГМУ, г. Пятигорск

Cand. Sci. (Pharm.), Associate Professor of the Department of Pharmacognosy, Botany and Technology of Phytopreparations, PMPhI - a branch of the VolgSMU, Pyatigorsk, Russian Federation

bergenya@yandex.ruПятигорский медико-фармацевтический институт - филиал Волгоградского государственного медицинского университета (ПМФИ - филиал ВолгГМУ)РоссияPyatigorsk Medical and Pharmaceutical Institute - a branch of Volgograd State Medical University (PMPhI - a branch of the VolgSMU)Russian Federation20222906202225297104Copyright © Федотова В.В., 20222022Федотова В.В.Fedotova V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.kursk-vestnik.ru/jour/article/view/1033

Цель: анализ и оценка данных научной литературы о необходимости применения растительных стеролов и станолов для лечения гиперхолестеринемии с целью снижения риска возникновения ишемической болезни сердца. Материалы и методы. Статья обобщает сведения научных публикаций в журналах поисковых систем PubMed, Scopus, Google Scholar, а также библиотечных баз данных (eLibrary). Результаты. Фитостеролы (фитостерины), фитостанолы - это липидоподобные соединения, которые встречаются в продуктах растительного происхождения. По своей структуре они сходны с холестерином и поэтому успешно конкурируют с ним за всасывание в кишечнике, снижая тем самым поступление холестерина в кровоток. В результате такой терапии гиперхолестеринемии уменьшается риск развития ишемической болезни сердца. В обзоре рассмотрены факторы, влияющие на эффективность использования стеролов/станолов, и пути совершенствования терапии с их использованием. Также представлено влияние станолов и на иммунную систему. Заключение. Продукты, обогащенные стеролами и станолами (йогурты, кефир, молоко, спреды и др.), являются перспективным средством в комплексе немедикаментозных мероприятий по уменьшению уровня холестерина ЛПНП, установленного фактора риска развития ИБС, а введение их в рацион питания будет способствовать профилактике ИБС среди населения России.

Objective: analyze and evaluate scientific literature data on the need for the use of plant sterols and stanols for the treatment of hypercholesterolemia in order to reduce the risk of coronary heart disease. Materials and methods. The article summarizes the information of scientific publications in the journals of search systems PubMed, Scopus, Google Scholar, as well as library databases (eLibrary). Results. Phytosterols (phytosterols), phytostanols, are lipid-like compounds found in foods of plant origin. Their structure is similar to cholesterol and therefore they successfully compete with it for absorption in the intestine, thus reducing the flow of cholesterol into the bloodstream. As a result of this therapy for hypercholesterolemia, the risk of coronary heart disease is reduced. The factors influencing the efficacy of sterols/stanols and ways to improve therapy with their use are discussed in the review. The effect of stanols on the immune system is also presented. Conclusion. Food products enriched with sterols and stanols (yoghurt, kefir, milk, spreads, etc.) are promising tools in the complex of non-medicinal measures to reduce LDL cholesterol levels, an established risk factor for CHD, and their introduction into the diet will contribute to the prevention of CHD among the Russian population.

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The authors declare that there are no conflicts of interest present.