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KURSKIY SCIENTIFICALLY-PRACTICAL HERALD"PERSONS AND HIS HEALTH"Scientifically-practical journal from Kursk state medical university, Central-Chernozemnogo scientific centre to Russian Academy of the Medical Sciences, Kursk regional branch of the Russian Academy of Natural SciencesFounded in 1998 ¹1 - 2010 YearQUESTIONS OF PHARMACYFull Russian article : Biopharmaceutical researches in vitro transdermal of plas-ters with Mexidol© Losenkova S.O., Stepanova E.F., Novikov V.E. Pharmaceutical Technology Department of the Smolensk State Medical Academy, Smolensk; Technology of Drugs Department of the Pyatigorsk State Pharmaceutical Academy, Pyatigorsk, Stavropol Region; Department of Pharmacology with a Course of Pharmacy FPQ of the Smolensk State Medical Academy, Smolensk Structures are developed and matrix plasters with Mexidol are designed. Process of liberation of medicinal substance of matrix compositions, tablets and a substance studied a biopharmaceutical method of a dialysis through a membrane on properties and structure close to natural membranes. As the dialysis environment pure water, which is similar to the blood system, has been used. Sampling carried out through certain time intervals. The quantity ofMexidol in dialysatum was analyzed by Uf-spektrofotometricheski. As the basic investigated parametres have been chosen quantity liberated of Mexidol (mkg/sm²), speed transdermal givings for a certain time interval (mkg/ch•sm²), degree of liberation (%) of Mexidol from a matrix. Key words: Mexidol, a plaster, a dialysis method, speed transdermal givings * For viewing of the full Russian version of article it is necessary Adobe Reader |
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