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KURSKIY SCIENTIFICALLY-PRACTICAL HERALD"PERSONS AND HIS HEALTH"Scientifically-practical journal from Kursk state medical university, Central-Chernozemnogo scientific centre to Russian Academy of the Medical Sciences, Kursk regional branch of the Russian Academy of Natural SciencesFounded in 1998 ¹1 - 2010 YearCLINICAL MEDICINEFull Russian article : Specific features of immune status of patients with combined herpes simplex virus and papilloma virus infection© Lukashov M.I., Bibicheva T.V., Isaenko T.P., Tarasova T.K. Kursk Regional Clinical Dermatovenerologycal Dispensary, Kursk; Dermatovenerology Department of the Kursk State Medical University, Kursk; Internal Diseases N 1 & Dermatovenerology Department of the Medical Faculty of the Belgorod State University, Belgorod The research was devoted to specific features of immune status of patients with combined herpes simplex virus and papilloma virus infection (HSV/HPV). The following changes has been revealed: significantly increased amount of NK-cells with prevalence of CD16-56+ NK phenotype; moderately increased amount of CD8+ Ò-cells with expression of HLA-DR, α-chain of Il-2 (CD25) receptor and formation of cells carrying both CD45RA and CD45RO types of molecules; decreased relative amount of CD4+ Ò-cells (as a result of hyperplasia of NK-cells) with shifted content of "memory" CD4+CD45RA-/RO+ cells and regulatory CD4+25+ cells; moderate monocytosis and increasing of band-formed neutrofiles; shifted levels of IgG and CIC. These changes are an evidence of a chronic active reaction of immune system on a viral infection as well as a beginning decompensation of some mechanisms of antiinfectious defense. Key words: herpes simplex virus infection, papilloma virus infection, immune system * For viewing of the full Russian version of article it is necessary Adobe Reader |
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