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KURSKIY SCIENTIFICALLY-PRACTICAL HERALD"PERSONS AND HIS HEALTH"Scientifically-practical journal from Kursk state medical university, Central-Chernozemnogo scientific centre to Russian Academy of the Medical Sciences, Kursk regional branch of the Russian Academy of Natural SciencesFounded in 1998 ¹1 - 2010 YearCLINICAL MEDICINEFull Russian article : Impact of Simvastatin on function of endothelium in patients with hypertensive intracerebral hemorrhage© Agzamov M.K., Ivanova N.E., Pavlov O.A., Nikitin A.I., Akhtamov D.A., Arzikulov T.N. Marian City Hospital, St.-Petersburg; Samarqand Office of the Special Medical Aid Republic Scientific Centre, Samarqand, Uzbekistan Examined 23 patients with hypertensive intracerebral hemorrhage in age from 41 to 72 years. Men were 15, women – 8. Patients in the second stage of hypertension was 7, in the third – 16. The basal ganglia or thalamus hemorrhage was in 19 and lobar in 4. The mean volume was 21.8±3.1 cm³. Patients study group (11 people), in addition to basic therapy received Simvastatin in a dose of 20 mg/day for a month. Laboratory methods included the definition of lipid spectrum, endothelium-dependent vasodilation, venous circulating endothelial cells (CECs) counts. The study showed that patients have a signs of impaired of lipid metabolism and signs of endothelial dysfunction, manifested in declining endothelium-dependent vasodilation and an increase of CECs counts. The study showed that use of the Simvastatin led to the normalization levels of cholesterol, also low-density lipoprotein cholesterol and improve endothelial dysfunction. Key words: hypertensive intracerebral hemorrhage, endothelial dysfunction, Simvastatin * For viewing of the full Russian version of article it is necessary Adobe Reader |
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