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KURSKIY SCIENTIFICALLY-PRACTICAL HERALD"PERSONS AND HIS HEALTH"Scientifically-practical journal from Kursk state medical university, Central-Chernozemnogo scientific centre to Russian Academy of the Medical Sciences, Kursk regional branch of the Russian Academy of Natural SciencesFounded in 1998 ¹1 - 2010 YearEXPERIMENTAL BIOLOGY AND MEDICINEFull Russian article : Antioxidant therapy at ishemic liver injury correction (the experimental research)© Bezhin A.I., Perkov A.A. Operative Surgery and Topographic Anatomy Department of the Kursk State Medical University, Kursk The experiment involved 35 dogs. The research is devoted to the influence of antioxidant anti-ischemic treatment complex which consists of Mexicor® and Actovegin® with temporary porto-caval shunting. The idea was to investigate it’s impact on the intensity of 30-minute ischemic injury of hepar tissue after hepatic-duodenum ligaments clamping. The animals were devived into 5 groups. The results showed that animals of the experimental group without antioxidant protection suffered from the development of cytolytic, cholestatic and hepatodepressive syndroms. In the groups with correction of ischemia by Mexicor and Actovegin, presented low changes of biochemical showings which normilized to the seventh day of experiment. The conclusion of the experiment is concentrated on the idea that the use of antioxidant anti-ischemic complex reduces the level of liver injury caused by oxygen starvation, prevents the development of ischemic modification in the organ and provides protective and treatment effects. Key words: Mexicor®, Actovegin®, hepar ischemia, anti-ischemic protection * For viewing of the full Russian version of article it is necessary Adobe Reader |
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